Patricia I Richards

US Patent:

8222267, Jul 17, 2012

Filed:

Jul 18, 2011

Appl. No.:

13/185016

Inventors:

Patricia T. Richards - West New York NJ, US
Warren C. Stern - Plymouth MA, US
Benjamin Schwartz - St. Louis MO, US

Assignee:

QRxPharma Ltd. - North Sydney

International Classification:

A01N 43/42
A01N 43/38
A01N 37/10
A61K 31/44
A61K 31/40
A61K 31/19
A61K 9/28
A61K 9/20
C07D 489/00

US Classification:

514282, 546 44, 514420, 514568, 424474, 424468

Abstract:

A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.