This invention is directed to tissue engineered prostheses made from processed tissue matrices derived from native tissues that are biocompatible with the patient or host in which they are implanted. When implanted into a mammalian host, these prostheses can serve as a functioning repair, augmentation, or replacement body part or tissue structure.
Andrew J. Nixon - East Wareham MA, US Ginger A. Abraham-Freel - Hanover MA, US Patrick R. Bilbo - Sudbury MA, US
Assignee:
Oranogenesis, In.c - Massachusetts
International Classification:
A61F 2/00 C12N 11/00 C12N 5/06
US Classification:
424423, 435174, 435325
Abstract:
Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs are biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.
Bioengineered Tissue Constructs And Cardiac Uses Thereof
Patrick R. Bilbo - Sudbury MA, US Dario C. Eklund - Canton MA, US
International Classification:
A61F 2/00 A61K 35/12
US Classification:
424423, 424 937
Abstract:
Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of multiple cell layers or more than one cell type. The tissue constructs of the invention have morphological features and functions similar to tissues their cells are derived and their strength makes them easily handleable. Preferred cultured tissue constructs of the invention are prepared in defined media, that is, without the addition of chemically undefined components. These tissue constructs are used to repair cardiac tissues.
Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs are biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.
Methods For Treating A Patient Using A Bioengineered Flat Sheet Graft Prostheses
This invention is directed to tissue engineered prostheses made from processed tissue matrices derived from native tissues that are biocompatible with the patient or host in which they are implanted. When implanted into a mammalian host, these prostheses can serve as a functioning repair, augmentation, or replacement body part or tissue structure.
Name / Title
Company / Classification
Phones & Addresses
Patrick Bilbo Vp Of Regulatory Affairs, Vp Regulatory, V P Clinical And Regulatory Affairs
Vice President, Regulatory Affairs & Government Relations. at Organogenesis Inc.
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
Organogenesis Inc. - greater boston area since Jan 1999
Vice President, Regulatory Affairs & Government Relations.
Cytyc Corporation (Hologic) 1994 - 1998
Director, Regulatory & Clinical Affairs
Stryker Corporation, Biotech Division 1992 - 1994
Clinical Research
Organogenesis 1987 - 1992
Product Development, Regulatory/Clinical Affairs
Harvard Medical School 1984 - 1987
Cell Biology Research
Education:
Boston University Graduate School of Management 1992
Masters Business Administration, Business Administration
Boston University Graduate School of Arts & Sciences 1991
Masters Degree, Technology Strategy & Policy
Boston University Graduate School of Arts & Sciences 1990
Masters Degree, Biology
Syracuse University 1984
Bachelors of Science, Biology