Patrick J Fleming

US Patent:

58932690, Apr 13, 1999

Filed:

Apr 23, 1998

Appl. No.:

9/065784

Inventors:

Patrick J. Fleming - Guilford CT
Gerald E. Johnson - Bethany CT
Alan M. Friedman - West Lafayette IN

Assignee:

Yale University - New Haven CT

International Classification:

F25B 1900
F25D 1702

US Classification:

62 511

Abstract:

A crystal freezing apparatus in accordance with the invention includes a first chamber for receiving a macromolecular structure and a second chamber which includes a cryogenic liquid holder. Gas inlets are provided for introducing a defined gas, such as Xenon at an elevated pressure, into both chambers. Introduction of the defined gas into the first chamber, enables atoms of the defined gas to enter void spaces in or onto the surface of the macromolecular structure while it is held in the first chamber. A valve structure is provided to connect the first and second chambers. A push rod assembly enables movement of the macromolecular structure from the first chamber to the second chamber, via the valve structure, all while under the influence of the defined gas. Once the macromolecular structure enters the second chamber, it is immersed into a cryogenic liquid so as to freeze the macromolecular structure with its included atoms of the defined gas.

US Patent:

52234843, Jun 29, 1993

Filed:

Nov 21, 1990

Appl. No.:

7/616910

Inventors:

Patrick J. Fleming - Annapolis MD
Ute M. Kent - Great Falls VA

Assignee:

Georgetown University - Washington DC

International Classification:

A61K 3700
C07K 500

US Classification:

514 14

Abstract:

A dodecapeptide for regulating weight gain in mammals, as defined in the sequence: CHHRKKGYADLY wherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A is alanine, D is aspartic acid and L is leucine; and the remaining amino acids are each independently glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, cystine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, lysine hydroxylysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, proline or hydroxyproline.