Anthony O. Chong - Huntsville AL, US Seoju Lee - Madison AL, US Bhalchandra V. Joshi - Madison AL, US Brian Bray - Huntsville AL, US Shaoyong Nie - Huntsville AL, US Patrick L. Spence - Madison AL, US Antoni Kozlowski - Huntsville AL, US Samuel P. McManus - Huntsville AL, US Sachin Tipnis - Houston TX, US Greg Lavaty - Sugar Land TX, US David Swallow - Spring TX, US John R. Handley - Duluth MN, US Anthony G. Schaefer - Huntsville AL, US
Assignee:
Nektar Therapeutics - San Francisco CA
International Classification:
C07D 491/22
US Classification:
514283, 546 48
Abstract:
Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
Acid Salt Forms Of Polymer-Drug Conjugates And Alkoxylation Methods
Anthony O. Chong - Huntsville AL, US Seoju Lee - Madison AL, US Bhalchandra V. Joshi - Madison AL, US Brian Bray - Huntsville AL, US Shaoyong Nie - Huntsville AL, US Patrick L. Spence - Madison AL, US Antoni Kozlowski - Huntsville AL, US Samuel P. McManus - Huntsville AL, US Sachin Tipnis - Houston TX, US Greg Lavaty - Sugar Land TX, US David Swallow - Sping TX, US John R. Handley - Duluth MN, US Anthony G. Schaefer - Huntsville AL, US
Assignee:
Nektar Therapeutics - San Francisco CA
International Classification:
C08G 65/48 A61K 47/48 C07C 51/41 C07C 53/18
US Classification:
514283, 546 48, 568620, 568623, 548520
Abstract:
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
Acid Salt Forms Of Polymer-Drug Conjugates And Alkoxylation Methods
- San Francisco CA, US Seoju Lee - Madison AL, US Bhalchandra V. Joshi - Madison AL, US Brian Bray - Huntsville AL, US Shaoyong Nie - Middleton WI, US Patrick L. Spence - Madison AL, US Antoni Kozlowski - Huntsville AL, US Samuel P. McManus - Guntersville AL, US Sachin Tipnis - Houston TX, US Greg Lavaty - Sugar Land TX, US David Swallow - Spring TX, US John R. Handley - Duluth MN, US Anthony G. Schaefer - Huntsville AL, US
Assignee:
NEKTAR THERAPEUTICS - San Francisco CA
International Classification:
A61K 47/48 A61K 31/4745 C08G 65/48
US Classification:
525 50
Abstract:
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
Medical School University of Texas Medical Branch at Galveston Graduated: 1993
Languages:
English
Description:
Dr. Spence graduated from the University of Texas Medical Branch at Galveston in 1993. He works in Columbus, OH and specializes in Anesthesiology. Dr. Spence is affiliated with Dublin Methodist Hospital and Riverside Methodist Hospital.
Mount Carmel Medical GroupMount Carmel Medical Group Taylor Station 150 Taylor Sta Rd STE 140, Columbus, OH 43213 (614)8560700 (phone), (614)8560790 (fax)
Mount Carmel Medical GroupMount Carmel Medical Group Victorian Village 100 W 3 Ave STE 250, Columbus, OH 43201 (614)2992557 (phone), (614)2999311 (fax)
Languages:
English
Description:
Mr. Spence works in Columbus, OH and 1 other location and specializes in Family Medicine. Mr. Spence is affiliated with Mount Carmel East Hospital and Mount Carmel West Hospital.
Such is the power of television. Such is the power of a nation brought to rage by such a naked abuse of power, said Mr. Bates producer Patrick Spence, who accepted with James Strong. May that be an inspiration to all of us.
Date: Jun 01, 2025
Category: Entertainment
Source: Google
Sonos CEO will testify to lawmakers after suing Google
Sonos CEO Patrick Spence is scheduled to appear alongside the founder and CEO of PopSockets, David Barnett, and the vice president and general counsel to Tile, Kirsten Daru, at the University of Colorado Law School. PopSockets has long struggled with infringing products, with one executive describin
The last time Sonos CEO Patrick Spence was on The Vergecast, he told me that one way Sonos had sped up its product cycles was by modularizing things: most Sonos products now use the same processor, networking components, and so on. If that approach can yield a $100 Ikea speaker complete with actua
Date: Dec 27, 2019
Category: Technology
Source: Google
Sonos acquires voice assistant startup Snips, potentially to build out on-device voice control
data they collect from users. Theyve introduced additional controls to help users navigate their own data sharing, but Sonos CEO Patrick Spence noted in an interview with Variety that one of the things the company can do in building its own voice features is developing them with privacy in mind.
Date: Nov 20, 2019
Category: Technology
Source: Google
More Music Tech Companies Mulling IPO After Spotify's Smooth Debut -- But Is It Really a Good Idea?
As early as Jan. 2017, Sonos newly-minted CEO Patrick Spence was "considering whether an IPO would be the next best thing," adding in interviews that his company was still profitable and growing comfortably. The new job listings add more color to this possibility, confirming that Sonos is in the p
Date: Apr 12, 2018
Category: Business
Source: Google
Sonos's Weird-Looking New Speaker Solves A Living Room Design Problem
speakers nonetheless caused the company to rethink its priorities. Sonos, which is now led by CEO Patrick Spence after longtime chief executive John MacFarlane stepped down earlier this year, is now focused on building integrations with voice control providers, starting with Amazons Alexa platform. I
Date: Mar 07, 2017
Category: Sci/Tech
Source: Google
Sonos unveils its first new speaker of 2017, the Sonos PLAYBASE
e think about what product well invent next, we think first about the home, and the role each of our products play in the home. What we realized is that PLAYBAR only met the need of the small percentage of homes where people mount their televisions on the wall, Sonos CEO Patrick Spence said. We s
Date: Mar 07, 2017
Category: Sci/Tech
Source: Google
Sonos Introduces PLAYBASE, An Off the Wall Approach to TV Sound
think about what product well invent next, we think first about the home, and the role each of our products play in the home. What we realized is that PLAYBAR only met the need of the small percentage of homes where people mount their televisions on the wall, said Sonos CEO, Patrick Spence. We s
Date: Mar 07, 2017
Category: Sci/Tech
Source: Google
Googleplus
Patrick Spence
Work:
Extension Gallery - Intern (2011)
Education:
University of Illinois at Chicago - Architecture
Tagline:
I study Architecture at UIC in Chicago. I love design, photography, traveling, technology and music and gardening
Bragging Rights:
Tennis, britney spears
Patrick Spence
Work:
Towne Park - GSC (overnight)
Education:
Florida International University - Mechanical Engineering
Tagline:
I'm cool
Patrick Spence
Work:
Walvisbay - Namibia
Education:
High School Etosha _ Tsumeb
Patrick Spence
About:
My day job is programming websites for non-profit associations. In my free time I dabble in photography, walk around and explore New York City, love to travel around the world, and I am currently lear...
Tagline:
Photographer, Flâneur, Traveler and thinker...
Patrick Spence
Patrick Spence
Patrick Spence
Patrick Spence
Youtube
We've seen things stabilize and a great respo...
Turn to CNBC TV for the latest stock market news and analysis. From ma...
Duration:
4m 55s
Sonos has 'never been working on this many pr...
Sonos CEO Patrick Spence sits down with Yahoo Finance Live's Brian Soz...
Duration:
7m 53s
Patrick Spence, Sonos CEO: A Fortt Knox Conve...
I speak with Sonos CEO Patrick Spence about thriving as a premium prod...
Duration:
57m 22s
Assassin's Creed 4: Black Flag (Sea Shanty Ed...
Stream/Download AC 4 Black Flag Sea Shanty Edition Listen to the f...
Duration:
1m 54s
Sir Patrick Spens - Nic Jones
Child Ballad #58.
Duration:
3m 54s
Sir Patrick Spens (Sandy Denny Vocal Version)
Provided to YouTube by Universal Music Group Sir Patrick Spens (Sandy ...