Paul W Chen

US Patent:

8158141, Apr 17, 2012

Filed:

Nov 9, 2005

Appl. No.:

11/270942

Inventors:

Paul Hong-Dze Chen - Rancho Santa Fe CA, US

International Classification:

A61F 2/00
C12N 11/02
C12N 11/10
C12N 11/08
C12N 5/07
C12M 1/00

US Classification:

424423, 435177, 435178, 435180, 435395, 4352831

Abstract:

A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.

US Patent:

20110008413, Jan 13, 2011

Filed:

Jul 7, 2010

Appl. No.:

12/831717

Inventors:

Yong Qiu - San Diego CA, US
James S. Kuo - San Diego CA, US
Geraldine P. Kuo - San Diego CA, US
Chin-Chih Chiang - San Diego CA, US
Paul R. Chen - San Diego CA, US

Assignee:

MSK PHARMA, LLC - San Diego CA

International Classification:

A61K 9/70
A61K 31/573
A61K 31/58
A61K 31/57
A61K 31/616
A61P 23/02
A61P 29/00

US Classification:

424448, 514171, 424449, 514161

Abstract:

The present invention generally relates to transdermal drug delivery systems. More particularly, the present invention provides compositions and transdermal drug delivery systems for the treatment and/or relief of symptoms associated with carpal tunnel syndrome or tendonitis.

US Patent:

20120191184, Jul 26, 2012

Filed:

Mar 30, 2012

Appl. No.:

13/436255

Inventors:

Paul Hong-Dze Chen - Rancho Santa Fe CA, US

International Classification:

A61F 2/14

US Classification:

623 516

Abstract:

A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.

US Patent:

20130053839, Feb 28, 2013

Filed:

Aug 23, 2011

Appl. No.:

13/215407

Inventors:

Robert Hotto - , US
Paul H. Chen - Rancho Santa Fe CA, US

International Classification:

A61B 18/04
A61B 18/06
A61B 18/18
A61B 18/10

US Classification:

606 30, 606 28

Abstract:

A system for suturing and cauterization is provided. A needle assembly and/or suture line emanates heat to cauterize tissue during wound closure. Energy sources for the heat include thermal elements of a variety of configurations energized from electrical, RF or chemical sources disposed internally or external to the needle assembly. Conductive suture lines are provided and some embodiments include a surgical robot. Wound closure is improved and closing time decreased while the potential for bleeding induced by needle tract incisions and suture tension is minimized.

US Patent:

20160058490, Mar 3, 2016

Filed:

Nov 12, 2015

Appl. No.:

14/939122

Inventors:

Robert Hotto - Carlsbad CA, US
Paul H. Chen - Carlsbad CA, US

International Classification:

A61B 18/08
A61B 18/14
A61B 18/10

Abstract:

A system for suturing and cauterization is provided. A needle assembly and/or suture line emanates heat to cauterize tissue during wound closure. Energy sources for the heat include thermal elements of a variety of configurations energized from electrical, RF or chemical sources disposed internally or external to the needle assembly. Conductive suture lines are provided and some embodiments include a surgical robot. Wound closure is improved and closing time decreased while the potential for bleeding induced by needle tract incisions and suture tension is minimized.

US Patent:

20160058491, Mar 3, 2016

Filed:

Nov 12, 2015

Appl. No.:

14/939171

Inventors:

Robert Hotto - Carlsbad CA, US
Paul H. Chen - Carlsbad CA, US

International Classification:

A61B 18/08
A61B 17/06
A61B 18/10

Abstract:

A system for suturing and cauterization is provided. A needle assembly and/or suture line emanates heat to cauterize tissue during wound closure. Energy sources for the heat include thermal elements of a variety of configurations energized from electrical, RF or chemical sources disposed internally or external to the needle assembly. Conductive suture lines are provided and some embodiments include a surgical robot. Wound closure is improved and closing time decreased while the potential for bleeding induced by needle tract incisions and suture tension is minimized.

US Patent:

20150133907, May 14, 2015

Filed:

Jan 22, 2015

Appl. No.:

14/603155

Inventors:

Paul H. Chen - Rancho Santa Fe CA, US
Robert Hotto - Carlsbad CA, US

International Classification:

A61B 18/10
A61B 18/08
A61B 18/14

US Classification:

606 30

Abstract:

A system and method for inhibiting bleeding during surgical wound closure is provided. As the surgical wound created as part of surgery is closed by a suture and needle, energy is applied to the needle causing bleeding tissue to cauterize thus inhibiting at least some of the bleeding that invariably accompanies surgery. The surgical needle is held by a needle holder or other device and that device holding the needle is connected to an energy source that can be controlled by the surgeon. As energy from the energy source is applied to the needle holder through a conductive line, it is conveyed to the surgical needle through the needle holder and the energy emanating from the needle cauterizes tissue and controls bleeding as the wound is sutured closed. Bleeding from the needle tract created by the puncture of the tissue by the sharp point of the needle and passage of the needle body into the tissue that would otherwise occur as a necessary part of suture is in particular inhibited. Use of the system and method in blepharoplasty is described.