Paul Chen

US Patent:

20050220375, Oct 6, 2005

Filed:

Feb 10, 2005

Appl. No.:

11/055575

Inventors:

Toby Thomas - Pleasant Prairie WI, US
William Belias - Pittsford NY, US
Paul Chen - Canandaigua NY, US
Nathan Kolovich - Round Lake IL, US

International Classification:

B65D033/00

US Classification:

383105000, 383040000, 383042000, 383006000

Abstract:

Packages with active agents are described. Generally, each disclosed package has a pair of opposing body panels joined together along a pair of opposing sides and a bottom bridging the sides, a reclosable fastener extending along a mouth formed opposite the bottom, and at least one active agent. The at least one active agent is associated with at least one of the body panels and includes a freshness-extension agent to inhibit spoilage of perishable product disposed in the package, an odor management agent to reduce, mask, or neutralize odors from garbage or waste disposed in the package, or another type of agent.

US Patent:

20070166344, Jul 19, 2007

Filed:

Jan 18, 2006

Appl. No.:

11/334049

Inventors:

Xin Qu - East Brunswick NJ, US
Rainer Gruening - Basking Ridge NJ, US
Karen Merritt - Hillsborough NJ, US
Paul Chen - Canandaigua NY, US
Vitaly Falevich - Parsippany NJ, US

International Classification:

A61K 31/787
A61F 2/02
C08G 63/91
C08L 75/00

US Classification:

424423000, 424405000, 424078300, 525127000, 525054200

Abstract:

Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings with long-lasting antimicrobial efficacy without formation of a zone of inhibition. Optionally the films can be hydrophilic. Specific long-chain molecules of certain chemical reactivity are covalently bonded into a polymeric matrix. They maintain a long-term anti-microbial efficacy without being leached out into the aqueous environment. The polymeric matrix of the compositions contain functional groups, which covalently bond to an amine, thiol, carboxyl, aldehyde or hydroxyl active group of selected long chain quaternary ammonium compounds. Upon formation of a covalent bonding with the polymeric matrix the long chain compounds become immobilized but still maintain antimicrobial efficacy. They do not leach out over extended period of time into the aqueous environment and maintain an anti-microbial efficacy against microorganisms. The coating is useful to prevent bacterial colonization on a variety of surface including surfaces of medical devices.

US Patent:

20080114096, May 15, 2008

Filed:

Nov 9, 2006

Appl. No.:

11/598223

Inventors:

Xin Qu - Hefei, CN
Tom Schottman - Flemington NJ, US
Rainer Gruening - Basking Ridge NJ, US
Paul N. Chen - Canandaigua NY, US
Joseph Conte - Monroe Twsp. NJ, US
Zheng Wang - Bridgewater NJ, US
Paaquale P. Vicario - North Plainfield NJ, US
Zichun Lu - Newton PA, US
Karen Meritt - Avon-By-The-Sea NJ, US
Dave Buongiovanni - Manville NJ, US

International Classification:

A61K 8/73
C08L 1/00

US Classification:

524 18, 427294, 4274274, 427457, 524 27, 524 35, 524 47, 524 56, 524 58

Abstract:

The invention provides a network composition comprising a plurality of associated saccharide chains wherein a chain comprises at least one saccharide component; and at least one first monomer, at least one second monomer, or combinations of both; wherein the first monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the second monomer is linked to the saccharide component by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages, aluminum oxide linkages; siloxane linkages; or combinations thereof; wherein first monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the first monomer is linked to the second monomer by ester linkages; ether linkages; amide linkages; ketone linkages; urea linkages; carbamate linkages; aluminum oxide linkages; siloxane linkages or combinations thereof; wherein the second monomers are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; polyvinyl linkages, polyolefin linkages, urea linkages; carbamate linkages, aluminum oxide linkages, siloxane linkages or combinations thereof; and wherein the saccharide components are linked to each other by ester linkages; ether linkages; amide linkages; ketone linkages; or combinations thereof; wherein the network is capable of adhering to a substrate.

US Patent:

57668655, Jun 16, 1998

Filed:

Jul 26, 1996

Appl. No.:

8/687640

Inventors:

Mann-Jy Chen - Wayne PA
Paul Chih-Hsueh Chen - Philadelphia PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

G01N 33567

US Classification:

435 721

Abstract:

A method of genetically engineering a cell line capable of detecting bioactive cytokines or growth factors is provided. Cells lines produced by this method and methods of using these cell lines to detect bioactive cytokines or growth factors in a biological fluid are also provided.