Paul S Cremer from 743 Mckee St, State College, PA 16803, age 57, Phone: (979)7773708

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Specialties:

Criminal Law
Appellate Practice
Administrative Law

ISLN:

912227472

Admitted:

1996

University:

University of South Dakota, B.S., 1991

Law School:

University of South Dakota, J.D., 1996

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Ph Modulation Method To Detect Ligand-Receptor Binding
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US Patent:

20120028823, Feb 2, 2012
Filed:

Dec 18, 2009
Appl. No.:

13/140228
Inventors:

Hyunsook Jung - Daejon, KR
Aaron D. Robison - Bryan TX, US
Paul S. Cremer - College Station TX, US
Assignee:

The Texas A&M University System - College Station TX
International Classification:

G01N 21/64
B01L 3/00
C07D 471/06
C40B 30/04
US Classification:

506 9, 436501, 422502, 422552, 422 69, 546 37
Abstract:

The present disclosure relates to detecting receptor-ligand binding by measuring local pH modulation using a pH-sensitive fluorophore.

Ph Modulation Methods And Systems For Detecting Binding Events
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US Patent:

20120142021, Jun 7, 2012
Filed:

Dec 1, 2011
Appl. No.:

13/309313
Inventors:

Paul S. Cremer - College Station TX, US
Assignee:

THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX
International Classification:

G01N 21/76
US Classification:

435 71, 436501
Abstract:

Methods and systems for detecting binding between first and second molecules using a pH-sensitive fluorophore. A change in fluorescence emission intensity of the fluorophore is indicative of binding.

Method And Apparatus For Temperature Gradient Microfluidics
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US Patent:

20040005720, Jan 8, 2004
Filed:

Oct 30, 2002
Appl. No.:

10/285323
Inventors:

Paul Cremer - College Station TX, US
Hanbin Mao - College Station TX, US
Tinglu Yang - College Station TX, US
International Classification:

G01N033/53
G01N033/543
C12M001/00
US Classification:

436/518000, 435/289100, 435/007100
Abstract:

The present invention is an apparatus for providing a linear temperature gradient to an architecture suitable for massively parallel chemical or biochemical processing. The architecture is disposed on a substrate. The apparatus uses two temperature elements disposed essentially parallel to each other and in thermal contact with the substrate. When the temperature elements are held at different temperatures, a linear temperature gradient is formed in the substrate.

Method And Apparatus For Temperature Gradient Microfluidics
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US Patent:

20210041379, Feb 11, 2021
Filed:

Mar 12, 2019
Appl. No.:

16/979682
Inventors:

- University Park PA, US
- Gaithersburg MD, US
Jifeng Zhang - Newton MA, US
Paul S. Cremer - State College PA, US
International Classification:

G01N 25/04
G01N 25/14
B01L 7/00
Abstract:

The present invention describes a versatile, robust and environmentally controlled platform with a linear temperature gradient for massively parallel chemical or biochemical processing. This apparatus is capable of probing the phase transition behavior of macromolecules in solution, both thermodynamically and kinetically. This includes- but is not limited to- liquid/liquid phase transition behavior of antibody solutions and in situ gelation of thermo-responsive polymers. The device can be operated in a multiplex fashion using a controlled temperature gradient architecture and visualized by dark field microscopy or by other optical intensity measurements.