Paul Ray Diaz

US Patent:

20060205026, Sep 14, 2006

Filed:

Dec 19, 2002

Appl. No.:

10/540277

Inventors:

Zhi Hong - Aliso Viejo CA, US
William Ricketts - Irvine CA, US
Paul Diaz - Riverside CA, US

Assignee:

Valeant Research & Development - Costa Mesa CA

International Classification:

C12Q 1/48
G06F 19/00

US Classification:

435015000, 702019000

Abstract:

A parallel inducible cell-based kinase screen (PICKS) includes a plurality of cells that express a kinase gene under the control of an inducer and a reporter gene, wherein the cells are derived from a single cell line, and wherein the reporter gene generate a signal in response to catalytic activity or inhibition of the expressed kinases. Particularly preferred systems include cells expressing kinases from a single kinase signaling pathway, kinases from a kinase family, and/or kinases from various different kinase signaling pathways. Consequently, contemplated systems provide a platform for screening for novel kinase inhibitors, inhibition specificity of particular kinase inhibitors, and for analysis of inter-pathway and/or intra-pathway inhibition of a kinase inhibitor.

US Patent:

20210032684, Feb 4, 2021

Filed:

Oct 19, 2020

Appl. No.:

17/073580

Inventors:

- San Diego CA, US
Scott WHITNEY - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

C12Q 1/6806
C12N 5/078
C12N 15/10
A01N 1/02

Abstract:

Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.

US Patent:

20210000103, Jan 7, 2021

Filed:

Sep 22, 2020

Appl. No.:

17/028068

Inventors:

- San Diego CA, US
Robyn RABAN - San Diego CA, US
Scott WHITNEY - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

A01N 1/02
C12N 5/078
A61B 5/15
B01L 3/00

Abstract:

The present invention relates to the stabilization of one or more metabolically-active cell in a blood sample at ambient temperatures. In particular, formulations, compositions, articles of manufacture, kits and methods for substantially stable storage of one or more metabolically-active cell in a blood sample at ambient temperatures are provided.

US Patent:

20200344999, Nov 5, 2020

Filed:

Jul 17, 2020

Appl. No.:

16/931698

Inventors:

- San Diego CA, US
Joel DESHARNAIS - La Mesa CA, US
Steven P. WILKINSON - San Diego CA, US
Victoria ARENDT - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

A01N 1/02
A61K 35/19

Abstract:

Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.

US Patent:

20180332841, Nov 22, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/049516

Inventors:

- San Diego CA, US
Joel DESHARNAIS - La Mesa CA, US
Steven P. WILKINSON - Poway CA, US
Victoria ARENDT - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

A01N 1/02
A61K 35/19

Abstract:

Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.

US Patent:

20170202211, Jul 20, 2017

Filed:

Jun 9, 2015

Appl. No.:

15/316686

Inventors:

- San Diego CA, US
Robyn RABAN - San Diego CA, US
Scott WHITNEY - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

A01N 1/02
A61B 5/15
B01L 3/00

Abstract:

The present invention relates to the stabilization of one or more metabolically-active cell in a blood sample at ambient temperatures. In particular, formulations, compositions, articles of manufacture, kits and methods for substantially stable storage of one or more metabolically-active cell in a blood sample at ambient temperatures are provided.

US Patent:

20170196220, Jul 13, 2017

Filed:

Jun 9, 2015

Appl. No.:

15/316677

Inventors:

- San Diego CA, US
Joel DESHARNAIS - La Mesa CA, US
Steven P. WILKINSON - Poway CA, US
Victoria ARENDT - San Diego CA, US
Paul DIAZ - Riverside CA, US

International Classification:

A01N 1/02

Abstract:

Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.

US Patent:

20170198335, Jul 13, 2017

Filed:

Jun 9, 2015

Appl. No.:

15/316680

Inventors:

- San Diego CA, US
Scott WHITNEY - San Diego CA, US
Paul DIAZ - Riverside CA, US

Assignee:

Biomatrica, Inc. - San Diego CA

International Classification:

C12Q 1/68
A01N 1/02

Abstract:

Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.