Paul F Grover

US Patent:

6337328, Jan 8, 2002

Filed:

Aug 18, 2000

Appl. No.:

09/640725

Inventors:

Qun Kevin Fang - Wellesley MA
Chrisantha Hugh Senanayake - Shrewsbury MA
Paul Grover - Franklin MA

Assignee:

Sepracor, Inc. - Marlborough MA

International Classification:

A61K 31535

US Classification:

5142312, 514649, 514653

Abstract:

Methods are disclosed which utilize metabolites of bupropion for treating sexual dysfunction.

US Patent:

6376684, Apr 23, 2002

Filed:

Nov 13, 2000

Appl. No.:

09/711776

Inventors:

Chris Hugh Senanayake - Shrewsbury MA
Paul T. Grover - Marlborough MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

C07D30793

US Classification:

549450, 562470, 562491, 562489, 562468

Abstract:

A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide a 5-(1-hydroxyalkyl)-5-phenyl-1,3-dioxolan-4-one, which is dehydrated to a 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one. The 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one may be hydrolyzed and reduced to an -alkylphenylglycolic acid or the hydrolysis and reduction steps may be reversed. The process enables the production of single enantiomers of cyclohexylphenylglycolic acid (CHPGA). An analogous process for racemic CHPGA is disclosed employing racemic mandelic acid and acetone. Novel intermediates in the process are also disclosed.

US Patent:

6780891, Aug 24, 2004

Filed:

Dec 2, 2002

Appl. No.:

10/308878

Inventors:

Chris Hugh Senanayake - Shrewsbury MA
Thomas P. Jerussi - Framingham MA
Paul T. Grover - Franklin MA
Qun Kevin Fang - Wellesly MA
Mark Currie - Sterling MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

C07C21101

US Classification:

514646, 564305, 564339, 564440

Abstract:

Compounds of formula I are effective in treating disorders modulated by opiate receptor activity and/or monoamine activity. In formula I, R is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl; R is selected from hydrogen, hydroxy, cyano, haloalkyl, glycosyl, SO R , and OR ; R and R are independently selected from hydrogen and lower alkyl, or R and R taken together with nitrogen form a five- or six-membered heterocyclic or substituted heterocyclic ring; and R is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl.

US Patent:

7018995, Mar 28, 2006

Filed:

Feb 20, 2003

Appl. No.:

10/369828

Inventors:

Mark G. Currie - Sterling MA, US
Steve Jones - Milford MA, US
Paul Grover - Franklin MA, US
Chris H. Senanayake - Brookfield CT, US

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 31/573
C07J 5/00
C07J 71/00

US Classification:

514179, 514180, 540 70, 552565, 552566

Abstract:

Carbonates and carbamates of the formula and related steroid carbonates and carbamates are disclosed. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

US Patent:

7148353, Dec 12, 2006

Filed:

Oct 28, 2004

Appl. No.:

10/976331

Inventors:

Kevin Fang - Wellesley MA, US
Paul Grover - Plainville MA, US
Thomas P. Jerussi - Charleston SC, US

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

C07D 471/02
A61K 31/44

US Classification:

546121, 514300

Abstract:

Imidazo[1,2-a]pyridines of the formulae I and II:.

US Patent:

7253156, Aug 7, 2007

Filed:

Feb 28, 2006

Appl. No.:

11/364659

Inventors:

Mark G. Currie - Sterling MA, US
Steve Jones - Milford MA, US
Paul Grover - Plainville MA, US
Chris H. Senanayake - Brookfield CT, US

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 31/56

US Classification:

514171

Abstract:

Compositions containing βadrenergic agonists in combination with carbonates and carbamates of the formula.

US Patent:

7468362, Dec 23, 2008

Filed:

Jul 13, 2007

Appl. No.:

11/777830

Inventors:

Mark G. Currie - Sterling MA, US
Steve Jones - Milford MA, US
Paul Grover - Plainville MA, US
Chris H. Senanayake - Brookfield CT, US

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 31/58
A61K 31/573
A61K 31/56

US Classification:

514174, 514179, 514180, 514870

Abstract:

Compositions containing βadrenergic agonists in combination with carbonates and carbonates of the formula.

US Patent:

7566725, Jul 28, 2009

Filed:

Sep 15, 2006

Appl. No.:

11/532402

Inventors:

Paul Grover - Plainville MA, US
Thomas P. Jerussi - Charleston SC, US

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A01N 43/42
A61K 31/44
C07D 491/02
C07D 498/02

US Classification:

514300, 546121

Abstract:

Imidazo[1,2-a]pyridines of the formulae I and II:.