Chris Hugh Senanayake - Shrewsbury MA Paul T. Grover - Marlborough MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
C07D30793
US Classification:
549450, 562470, 562491, 562489, 562468
Abstract:
A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide a 5-(1-hydroxyalkyl)-5-phenyl-1,3-dioxolan-4-one, which is dehydrated to a 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one. The 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one may be hydrolyzed and reduced to an -alkylphenylglycolic acid or the hydrolysis and reduction steps may be reversed. The process enables the production of single enantiomers of cyclohexylphenylglycolic acid (CHPGA). An analogous process for racemic CHPGA is disclosed employing racemic mandelic acid and acetone. Novel intermediates in the process are also disclosed.
Chris Hugh Senanayake - Shrewsbury MA Thomas P. Jerussi - Framingham MA Paul T. Grover - Franklin MA Qun Kevin Fang - Wellesly MA Mark Currie - Sterling MA
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
C07C21101
US Classification:
514646, 564305, 564339, 564440
Abstract:
Compounds of formula I are effective in treating disorders modulated by opiate receptor activity and/or monoamine activity. In formula I, R is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl; R is selected from hydrogen, hydroxy, cyano, haloalkyl, glycosyl, SO R , and OR ; R and R are independently selected from hydrogen and lower alkyl, or R and R taken together with nitrogen form a five- or six-membered heterocyclic or substituted heterocyclic ring; and R is selected from alkyl, aryl, alkylaryl, substituted alkyl, substituted aryl, and substituted alkylaryl.
Robert Paul Properties Inc Osterville, MA (508)8125547 (Phone)
About:
Paul Grover has been a leader in the marketing of waterfront properties on Cape Cod since 1981. In 1994, Paul co-founded Kinlin Grover Properties specializing in the sale of waterfront homes. In 1999, after five years of extraordinary success, the company was acquired by GMAC. In 2006, 2007 and 2008, Paul achieved the distinction of being one of the nation's Top 200 agents. In 2009, Paul again launched his own company, Robert Paul Properties, Inc., with his business partner, Bob Kinlin. Intelligent advice, hyper-local knowledge, a high-energy work ethic and constant innovation are the hallmarks of their business vision and growth. Robert Paul Properties will provide a very disciplined and specialized approach to real estate sales. With a synergy-based model, everyone is paying attention to every detail, supports each other, and shares their areas of expertise. Positioning a significant home in the marketplace to ensure it receives the most attention, and working with a buyer to produce a desired result, takes the highest level of execution. Paul has made it a point in his career to always raise the bar of excellence and give the most time and care to his career and colleagues. As Bruce, a recent client wrote, "Paul is the best of the best".
Agno Pharma
Senior Director of Business Development
Agno Pharma May 1, 2014 - Feb 2017
Director of Business Development at Agno Pharma
Neco Feb 2013 - Dec 2013
Student
Tedor Pharma, Inc. Aug 2012 - Feb 2013
Senior Scientist
Astrazeneca Mar 2010 - Dec 2012
Synthetic Chemist
Education:
Indiana University Bloomington 1988 - 2003
Doctorates, Doctor of Philosophy
Northeastern University 1982 - 1987
Bachelors, Bachelor of Science, Chemistry
New England College of Optometry
Skills:
Drug Discovery Organic Synthesis Medicinal Chemistry Hplc Organic Chemistry Chemistry Drug Design Gmp Oncology Cro Synthetic Organic Chemistry Gas Chromatography Patents Lead Change Clinical Development In Vivo
Paul Grover / Pool via AP The Duke and Duchess of Cambridge and the Duke and Duchess of Sussex attend a National Service to mark the centenary of the Armistice at Westminster Abbey.
Date: Nov 12, 2018
Category: Headlines
Source: Google
Taylor Swift on serial boyfriends, home buying in Vanity Fair
We ran that by Paul Grover of Robert Paul Properties, which has a handle on the disposition of every significant waterfront parcel on the Cape, and he confirmed that the property has changed hands in the past month or so.