Paul R Heaney

US Patent:

59618000, Oct 5, 1999

Filed:

May 8, 1997

Appl. No.:

8/848413

Inventors:

Sterling Eduard McBride - Lawrenceville NJ
William Chiang - Monmouth Junction NJ
Paul James Heaney - Skillman NJ
Satyam Choudary Cherukuri - Cranbury NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

204450

Abstract:

Provided is an electrode-based pump having source of a pumped fluid, a conduit channel of capillary dimensions connected via a first end to the pumped fluid source and having an outlet at a second end, a piston channel with a first end that intersects the conduit channel, wherein the piston channel allows for periodic inward and outward movement of a piston plug of liquid, two or more electrodes inserted into the piston channel which define an electrode-based pump, wherein the electrode-based pump can be operated to move the piston plug of liquid inward and outward.

US Patent:

58726233, Feb 16, 1999

Filed:

Sep 26, 1996

Appl. No.:

8/721427

Inventors:

Paul J. Stabile - Langhorn PA
David Norman Ludington - Newtown PA
Pamela Kay York - Yardley PA
Arye Rosen - Cherry Hill NJ
Satyam Choudary Cherukuri - Cranbury NJ
Peter John Zanzucchi - Lawrenceville NJ
Paul Heaney - Plainsboro NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2100

US Classification:

356 73

Abstract:

The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising: for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle that can be the same as the first angle.

US Patent:

59087552, Jun 1, 1999

Filed:

Oct 15, 1997

Appl. No.:

8/950709

Inventors:

Rajan Kumar - Robbinsville NJ
Paul Heaney - Plainsboro NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

C12Q 168
C12P 1934
G01N 3348

US Classification:

435 6

Abstract:

In one aspect, described are methods of sequencing of polynucleotides using a sequential step procedure. The methods of the invention begin with the provision of a single-stranded polynucleotide template that is annealed with a primer, forming a template-primer complex. The methods of the invention can provide for adding discrete nucleotides by a polymerase to the template-primer complex, where the added nucleotides can be labeled. The methods of the invention can involve the identification of a polynucleotide or polynucleotides having a contiguous non-redundant string or a superimposed non-redundant string pattern. The detection of the presence of a non-redundant contiguous string can be used, for example, to identify a particular gene. Alternatively, for example, if the non-redundant contiguous string is not unique to a particular gene, the string can be used to form a DNA library that can then be searched, for example, with a second string. Similarly, a superimposed non-redundant string pattern can be used, for example, to identify a gene or to search a DNA library.

US Patent:

59928204, Nov 30, 1999

Filed:

Nov 19, 1997

Appl. No.:

8/974258

Inventors:

Thomas Louis Fare - Yardley PA
Zhonghui Hugh Fan - Plainsboro NJ
Paul James Heaney - Skillman NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2726

US Classification:

25112901

Abstract:

Provided is a fluid control device comprising: (a) a channel of capillary dimensions for conveying a liquid, (b) a bubble-forming device for forming a channel-blocking bubble in the channel, wherein such a bubble formed in the channel impedes the flow of the liquid through the channel.

US Patent:

58546847, Dec 29, 1998

Filed:

Sep 26, 1996

Appl. No.:

8/721432

Inventors:

Paul J. Stabile - Langhorn PA
David Norman Ludington - Newtown PA
Pamela Kay York - Yardley PA
Arye Rosen - Cherry Hill NJ
Satyam Choudary Cherukuri - Cranbury NJ
Peter John Zanzucchi - Lawrenceville NJ
Paul Heaney - Plainsboro NJ

Assignee:

Sarnoff Corporation - Princeton NJ

International Classification:

G01N 2100

US Classification:

356440

Abstract:

The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from a first set of two or more detection sites on a planar substrate while spatially resolving the measurements from each first set detection site, the apparatus comprising: a source of a light beam directed towards the planar substrate at a first angle; one or more lenses for focusing light emitted or reflected from each of the first set detection sites and having a second angle having an angle offset from the first angle, onto a unique area of an array detector; and the array detector comprising a plurality of light responsive pixels, wherein for each first detection site there is at least one light responsive pixel that receives light emitted or reflected from that detection site and substantially no cross-talk from another detection site, and wherein substantially none of the light from the light source intersects with the array detector.