Paul W Kopesky

US Patent:

6918991, Jul 19, 2005

Filed:

Jan 7, 2004

Appl. No.:

10/752910

Inventors:

Sridhar Narasimhan - Framingham MA, US
David Altreuter - Brookline MA, US
Paul Kopesky - Quincy MA, US
Mark Keegan - Andover MA, US
Julie A. Straub - Winchester MA, US
Howard Bernstein - Cambridge MA, US

Assignee:

Acusphere, Inc. - Watertown MA

International Classification:

B01D001/16

US Classification:

159 481, 264 12, 159 401

Abstract:

Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e. g. , a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

US Patent:

6921458, Jul 26, 2005

Filed:

Jan 7, 2004

Appl. No.:

10/752861

Inventors:

Sridhar Narasimhan - Framingham MA, US
David Altreuter - Brookline MA, US
Paul Kopesky - Quincy MA, US
Mark Keegan - Andover MA, US
Julie A. Straub - Winchester MA, US
Howard Bernstein - Cambridge MA, US

Assignee:

Acusphere, Inc. - Watertown MA

International Classification:

B01D001/16

US Classification:

159 481, 264 12, 159 401

Abstract:

Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e. g. , a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

US Patent:

6962006, Nov 8, 2005

Filed:

Dec 19, 2002

Appl. No.:

10/324943

Inventors:

Sridhar Narasimhan - Framingham MA, US
David Altreuter - Brookline MA, US
Paul Kopesky - Quincy MA, US
Mark Keegan - Andover MA, US
Julie A. Straub - Winchester MA, US
Howard Bernstein - Cambridge MA, US

Assignee:

Acusphere, Inc. - Watertown MA

International Classification:

F26B003/08

US Classification:

34360, 159 481

Abstract:

Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e. g. , a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

US Patent:

20040121005, Jun 24, 2004

Filed:

May 19, 2003

Appl. No.:

10/441440

Inventors:

David Altreuter - Brookline MA, US
Julie Straub - Winchester MA, US
Howard Bernstein - Cambridge MA, US
Donald Chickering - Framingham MA, US
Paul Kopesky - Quincy MA, US
Greg Randall - Somerville MA, US

Assignee:

Acusphere, Inc.

International Classification:

A61K031/415
A61K009/20

US Classification:

424/465000, 514/406000

Abstract:

One or more COX-2 inhibitors are provided in a porous matrix form wherein the dissolution rate of the drug is enhanced when the matrix is contacted with an aqueous medium. The porous matrix yields upon contact with an aqueous medium nanoparticles and microparticles of COX-2 inhibitors having a mean diameter between about 0.01 and 5 m and a total surface area greater than about 0.5 m/mL. The dry porous matrix preferably is in a dry powder form having a TAP density less than or equal to 1.0 g/mL. The porous COX-2 inhibitor matrices preferably are made using a process that includes (i) dissolving one or more COX-2 inhibitors in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the dry porous matrix of COX-2 inhibitors. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug.

US Patent:

20050209099, Sep 22, 2005

Filed:

Jun 2, 2005

Appl. No.:

11/142917

Inventors:

Donald Chickering - Framingham MA, US
Sridhar Narasimhan - Framingham MA, US
David Altreuter - Brookline MA, US
Paul Kopesky - Quincy MA, US
Mark Keegan - Andover MA, US
Julie Straub - Winchester MA, US
Howard Bernstein - Cambridge MA, US

International Classification:

B01J023/00

US Classification:

502314000

Abstract:

Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with “in-line” jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.

US Patent:

20170327556, Nov 16, 2017

Filed:

Jan 5, 2017

Appl. No.:

15/399138

Inventors:

- Cambridge MA, US
Dmitri B. KIRPOTIN - Revere MA, US
Paul KOPESKY - Lexington MA, US
Alexey Alexandrovich LUGOVSKOY - Belmont MA, US
Rachel RENNARD - Stoneham MA, US
Birgit M. SCHOEBERL - Cambridge MA, US

International Classification:

C07K 14/65
C07K 14/47
A61K 38/30
A61K 9/00
A61K 31/573
A61K 9/50
A61K 9/127
A61K 9/00
A61K 38/17
A61K 38/00

Abstract:

Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain that specifically binds to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins. Methods of treating musculoskeletal diseases using the fusion proteins and pharmaceutical composition disclosed herein are also provided.

US Patent:

20160122411, May 5, 2016

Filed:

Mar 28, 2014

Appl. No.:

14/770749

Inventors:

- Cambridge MA, US
Dmitri B. Kirpotin - Revere MA, US
Paul Kopesky - Lexington MA, US
Alexey Lugovskoy - Woburn MA, US
Rachel Rennard - Stoneham MA, US

Assignee:

Merrimack Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 14/65
A61K 38/30
A61K 9/00
A61K 31/573
A61K 9/50
A61K 9/127
C07K 14/47
A61K 38/17

Abstract:

Provided herein are fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain that specifically binds to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins. Methods of treating musculoskeletal diseases using the fusion proteins and pharmaceutical composition disclosed herein are also provided.