Paul A Morton

US Patent:

20200289250, Sep 17, 2020

Filed:

Sep 6, 2018

Appl. No.:

16/645221

Inventors:

- Washington DC, US
- College Park MD, US
Masaaki TORII - Bethesda MD, US
Paul D. MORTON - Silver Spring MD, US
Seiji ISHII - North Bethesda MD, US
Justin OPFERMANN - Washington DC, US
Judy LIU - Washington DC, US
John FISHER - Kensington MD, US
Marco SANTORO - Silver Spring MD, US
Peter C.W. KIM - Washington DC, US

International Classification:

A61F 2/00
A61F 2/02
A61L 31/04
A61L 31/14
A61K 38/17
A61K 35/30

Abstract:

Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interior void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.