Paul Matthew O'Brien

US Patent:

60371293, Mar 14, 2000

Filed:

May 28, 1998

Appl. No.:

9/086372

Inventors:

David J. Cole - Mt. Pleasant SC
Paul L. Baron - Charleston SC
Paul H. O'Brien - Charleston SC

Assignee:

Medical University of South Carolina - SC

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

A method of detecting the metastasis of primary breast cancer to a lymph node is provided, comprising detecting, in lymph node tissue, the presence of a nucleic acid of c-myc, PIP or keratin-19. The presence of any one of these nucleic acids in lymph node tissue is associated with metastatic breast cancer. The presence of one or more of these markers in lymph node tissue or other tissue indicates that cells from the primary tumor have migrated from the breast tissue to the lymph node or other tissue. Also provided is a method of predicting the histopathologic stage of a cancer in a patient without having to perform a histopathologic analysis, comprising detecting, in lymph node tissue from the patient, the presence of a nucleic acid of c-myc, the presence of a nucleic acid of c-myc being correlated with stage I cancer as determined by histopathology. Alternatively, the absence of a nucleic acid of PIP and the absence of a nucleic acid of keratin-19 are correlated with stage I cancer as determined by histopathology. In another embodiment, the presence of a nucleic acid of PIP is correlated with stages later than stage I cancer as determined by histopathology.

US Patent:

47633530, Aug 9, 1988

Filed:

Feb 14, 1986

Appl. No.:

6/830058

Inventors:

Leonard M. Canale - Middletown NJ
Michael J. Collins - East Windsor NJ
Paul J. O'Brien - Atlantic Highlands NJ
Lisa L. Scott - Fair Haven NJ
Martin H. Singer - Fair Haven NJ

Assignee:

American Telephone and Telegraph Company - New York NY
AT&T Information Systems Inc. - Morristown NJ

International Classification:

H04M 350

US Classification:

379157

Abstract:

An adjunct call manager unit connects to a station set port of a telephone communication system and receives button identification and status signals to determine line, agent, and feature activation status of the system. In response to one or more of the received status signals, commands are sent to the system using button depression commands and switchhook commands to effectuate call processing control over the system. In one embodiment, the adjunct unit functions as an automated call distributor for managing incoming calls to the system.

US Patent:

44676212, Aug 28, 1984

Filed:

Sep 22, 1982

Appl. No.:

6/421320

Inventors:

Paul R. O'Brien - Falls Church VA

International Classification:

F25B 1300

US Classification:

623241

Abstract:

A fluid/vacuum chamber (FVC) is disclosed comprising a rigid porous membrane element wherein a vacuum is applied to one side of the porous element and a fluid is passed along the other side of the porous element to remove the heat of vaporization via the pressure differential. This chamber is useful as to reduce energy consumption in a desalination unit, a heat pump, an ice-making system and refrigeration systems. The porous material may be constructed of sintered brass, sintered stainless steel, polymeric plastic, a paper filter element, etc. in order to provide porous openings, of about 5 to about 100 microns. Also disclosed is the use of a fluid/vacuum chamber (FVC) in a heating cycle or cooling cycle. A compressor or vacuum pump normally provides the vacuum suction for the fluid/vacuum chamber (FVC).

US Patent:

53965485, Mar 7, 1995

Filed:

Mar 8, 1993

Appl. No.:

8/027976

Inventors:

Jeanne P. Bayerl - Red Bank NJ
Paul J. O'Brien - Atlantic Highlands NJ
Pamela A. Savage - Howell NJ

Assignee:

AT&T Corp. - Murray Hill NJ

International Classification:

H04M 1500
H04M 1506
H04M 100
H04M 342

US Classification:

379140

Abstract:

A communication system detects special service information (e. g. , calling party identification) during a silent interval between ringing signals on an incoming call and stores the information in a call record created for the call. In response to predetermined call conditions, this information is included as part of a control signal sent over an extension loop to a station terminal. Call features such as delayed ringing, hold, call transfers, line preselect and switch hook status are utilized to control where, when and if this information should be displayed at various station terminals.