Paul T Rhodes

US Patent:

20130303929, Nov 14, 2013

Filed:

May 9, 2012

Appl. No.:

13/467366

Inventors:

Raymond Anthony MARTINO - Los Gatos CA, US
Sung Hyun Lim - Mountain View CA, US
Paul A. Rhodes - Woodside CA, US

Assignee:

ISENSE Medical Corp - West Palm Beach FL

International Classification:

A61B 5/097

US Classification:

600532

Abstract:

An upper respiratory bacterial infection is detected from exhaled mammalian breath by using a colorimetric sensor array having a spectral response characteristic that changes when exposed to bacteria-produced analytes in the exhaled breath. A flow regulating system directs a leading portion of the exhaled breath into gaseous communication with the array to change its spectral response characteristic, and discharges a trailing portion of the exhaled breath exteriorly of the apparatus. A spectral analysis system analyzes the spectral response characteristic changed solely by the leading portion of the exhaled breath, and detects the upper respiratory bacterial infection when the bacteria-produced analytes are present therein. Reactivity of the analytes with the array is increased by advance oxidizing and/or heating the analytes.

US Patent:

20210310040, Oct 7, 2021

Filed:

Jun 7, 2021

Appl. No.:

17/341300

Inventors:

- West Palm Beach FL, US
Raymond Anthony Martino - Los Gatos CA, US
Paul A. Rhodes - Woodside CA, US
Richard Shu-Chung Huang - Palo Alto CA, US
Sung Hyun Lim - Mountain View CA, US

Assignee:

Specific Technologies, LLC - West Palm Beach FL

International Classification:

C12Q 1/18
G01N 33/52

Abstract:

Devices, systems, and methods for species and/or strain specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism. An exemplary method according to an embodiment of the present disclosure can include culturing a sample that contains microorganisms. The sample can be in a medium which is exposed to a colorimetric sensor array. A test substance can be introduced to the sample. The method can assess a susceptibility of the microorganisms to the test substance based on a change in at least one sensor in the colorimetric sensor array. Sensors in the colorimetric sensor array can change in response to volatile organic compounds produced by the microorganisms after addition of the test sub stance.

US Patent:

20180282780, Oct 4, 2018

Filed:

Mar 29, 2018

Appl. No.:

15/939736

Inventors:

- West Palm Beach FL, US
Raymond Anthony Martino - Los Gatos CA, US
Paul A. Rhodes - Woodside CA, US
Richard Shu-Chung Huang - Palo Alto CA, US
Sung Hyun Lim - Mountain View CA, US

Assignee:

Specific Technologies, LLC - West Palm Beach FL

International Classification:

C12Q 1/18

Abstract:

Devices, systems, and methods for species and/or strain specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism. An exemplary method according to an embodiment of the present disclosure can include culturing a sample that contains microorganisms. The sample can be in a medium which is exposed to a colorimetric sensor array. A test substance can be introduced to the sample. The method can assess a susceptibility of the microorganisms to the test substance based on a change in at least one sensor in the colorimetric sensor array. Sensors in the colorimetric sensor array can change in response to volatile organic compounds produced by the microorganisms after addition of the test substance.

US Patent:

20160282352, Sep 29, 2016

Filed:

Nov 6, 2014

Appl. No.:

15/034153

Inventors:

- West Palm Beach FL, US
Sung Hyun LIM - Mountain View CA, US
Paul A. RHODES - Woodside CA, US

International Classification:

G01N 33/574

Abstract:

A urine test for diagnosing lung cancer has been developed that uses an artificial nose such as a colorimetric sensor arrays to identify metabolic profiles in urine headspace gas. Cancer cells excrete unique compounds that are a byproduct of their metabolism. The compounds are excreted through a patient's endocrine system by filtration through the kidneys and other organs and are ultimately excreted through the urine. Some of these cancer cell by-products excrete in the urine are small volatile organic compounds (VOCs). Once the urine has exited the body, these VOCs may be outgassed to the environment. Experimental research has determined that a colorimetric sensor array as disclosed is capable of reliably identifying patients with lung cancer based after exposure to the VOCs of the urine headspace gas.

US Patent:

20150099694, Apr 9, 2015

Filed:

Apr 26, 2013

Appl. No.:

14/396685

Inventors:

- West Palm Beach FL, US
Raymond Anthony Martino - Los Gatos CA, US
Paul A. Rhodes - Woodside CA, US

Assignee:

Specific Technologies LLC - West Palm Beach FL

International Classification:

C12Q 1/04
C40B 30/02

US Classification:

514 27, 435 34, 506 8

Abstract:

Devices, systems, and methods for strain-specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism.