Paul R Stauffer

US Patent:

7582050, Sep 1, 2009

Filed:

Mar 30, 2005

Appl. No.:

11/093717

Inventors:

Jaime L. Schlorff - Phoenixville PA, US
Paul R. Stauffer - San Rafael CA, US

Assignee:

The Regents of the University of California - Oakland CA
Bionix Development Corporation - Toledo OH

International Classification:

A61N 5/02

US Classification:

600 2

Abstract:

A combination applicator is able to deliver heat and radiation, either simultaneously or sequentially, for the treatment of cancer or other disease. The combination applicator is flexible and able to conform to contoured anatomy of the patient. The combination applicator comprises a flexible, dielectric containing compartment having a tissue-engaging surface and an opposite, non-tissue-engaging surface. A heating surface comprising one or more RF or microwave antennas or ultrasound transducers is supported adjacent to the non-tissue-engaging surface. In addition, a plurality of conduits are also supported on the dielectric containing compartment, the conduits being adapted to communicate with at least one brachytherapy source. Additional conduits may be located on the tissue contacting surface of the dielectric containing compartment to accommodate moving or stationary temperature monitoring sensors.

US Patent:

8075181, Dec 13, 2011

Filed:

May 29, 2009

Appl. No.:

12/475151

Inventors:

Paul Rath Stauffer - Durham NC, US
Celestino John Gaeta - Carlsbad CA, US
Richard Alan Forber - Carlsbad CA, US
Doug Peder Bonnell - Castle Rock CO, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01K 3/00
G01K 13/00
G01J 5/00
A61B 5/00

US Classification:

374137, 374121, 374131, 600 2, 600549, 607101

Abstract:

A thermal monitoring sheet measures surface temperature distributions of large areas, even over large, contoured surfaces. The sheet incorporates conduits that terminate or intersect at temperature measurement locations with a fixed relative arrangement to form a two-dimensional grid for sensing temperature distributions.

US Patent:

20110117202, May 19, 2011

Filed:

Nov 10, 2010

Appl. No.:

12/943787

Inventors:

Zakaryae Fathi - Raleigh NC, US
Ian Nicholas Stanton - Durham NC, US
Michael J. Therien - Durham NC, US
Paul Rath Stauffer - Durham NC, US
Paolo MacCarini - Durham NC, US
Katherine Sarah Hansen - Cary NC, US
Diane Renee Fels - Morrisville NC, US
Cory Robert Wyatt - Durham NC, US
Mark Wesley Dewhirst - Durham NC, US

Assignee:

Immunolight, LLC - Detroit MI
Duke University - Durham NC

International Classification:

A61N 5/00
H01J 61/00
H01J 61/20
B01J 8/18
B01J 19/08
A61K 9/14
A61K 38/20
A61K 39/395
A61K 38/44
A61K 33/00
A61K 33/38
A61K 33/24
A61K 38/28
A61K 38/22
A61K 38/14
A61K 31/7052
A61K 31/7084
A61K 31/655
A61K 31/5415
A61K 31/525
A61K 31/473
A61K 31/47
A61K 31/40
A61K 31/405
A61K 31/352
A61K 31/122
A61K 31/015
C08G 77/00
A61L 2/10
G21G 5/00
A61M 37/00
B01J 19/12
C23C 14/28
B32B 37/00
B29C 65/14
B82Y 15/00
B82Y 25/00
B82Y 99/00

US Classification:

424490, 2504921, 313567, 313639, 422139, 422186, 424 852, 4241301, 424 944, 424600, 424618, 424649, 514 59, 514 97, 514 209, 514 43, 514 44 R, 514150, 5142248, 514251, 514297, 514298, 514299, 514410, 514415, 514454, 514455, 514457, 514688, 514765, 528 10, 604 20, 2041582, 2101981, 427595, 1563796, 1562739, 1562755, 1563797, 977742, 977773, 977904, 977932, 977750, 977752

Abstract:

Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λto the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.

US Patent:

56366329, Jun 10, 1997

Filed:

Mar 9, 1994

Appl. No.:

8/208936

Inventors:

Durairaj Bommannan - San Francisco CA
Hirohisa Okuyama - San Francisco CA
Richard H. Guy - San Francisco CA
Paul Stauffer - San Rafael CA
Gordon L. Flynn - Ann Arbor MI

Assignee:

Cygnus, Inc. - Redwood City CA
The Regents of the University of California - Oakland CA

International Classification:

H61B 500

US Classification:

128632

Abstract:

A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultra sound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.

US Patent:

52319750, Aug 3, 1993

Filed:

Mar 2, 1992

Appl. No.:

7/844732

Inventors:

Durairaj Bommannan - San Francisco CA
Hirohisa Okuyama - San Francisco CA
Richard H. Guy - San Francisco CA
Paul Stauffer - San Rafael CA
Gordon L. Flynn - Ann Arbor MI

Assignee:

Cygnus Therapeutic Systems - Redwood City CA
Regents of the University of California - Oakland CA

International Classification:

A61B 1700
A61M 3700

US Classification:

128 24AA

Abstract:

A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.

US Patent:

48258806, May 2, 1989

Filed:

Jun 19, 1987

Appl. No.:

7/084334

Inventors:

Paul R. Stauffer - San Rafael CA
Toru Satoh - San Francisco CA

Assignee:

The Regents of the University of California - Berkeley CA

International Classification:

A61N 502

US Classification:

128804

Abstract:

An implantable helical coil microwave antenna, particularly adapted for interstitial hyperthermia therapy of cancer, comprises a coaxial cable having a distal end of its outer conductor removed and a helical coil mounted on the exposed inner conductor insulator. A proximal end of the helical coil is separated axially from the distal end of the outer conductor and the distal end of the helical coil is connected to the inner conductor of the coaxial cable feed line. The antenna functions to confine heat to the area immediately surrounding the coil and thus induces substantially identical thermal profiles at varying antenna insertion depths in tissue when the antenna is energized with microwave energy.

US Patent:

63304791, Dec 11, 2001

Filed:

Dec 6, 1999

Appl. No.:

9/455303

Inventors:

Paul R. Stauffer - San Rafael CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61F 200

US Classification:

607101

Abstract:

A flexible microwave applicator and method of use thereof. The applicator includes a flexible, dielectric-containing compartment (e. g. temperature regulated water or oil) having a variable contour, tissue-engaging surface and an opposite non-tissue-engaging surface and an antenna array adjacent to a non-tissue-engaging surface. The antenna array includes at least one flexible printed circuit board having a front metal surface, a dielectric substrate, a back metal surface, a connection structure for connecting the antenna array to at least one external microwave device, at least one dual concentric conductor aperture on the front surface, and at least one microstrip feedline in communication with the dual concentric conductor aperture and the connection structure. The microwave applicator also includes flexible attachment material for placement over the antenna array and dielectric compartment to allow the microwave applicator to be attached to a subject like a garment which closely conforms to the anatomy portion to be heated. The flexible attachment material may be configured such that the microwave applicator is configured as an appropriately-shaped type of garment, for example, a vest, jacket, cap, hood, blanket, custom shaped conformal wrap, sleeve, or as a pair of shorts.

US Patent:

53237692, Jun 28, 1994

Filed:

Aug 2, 1993

Appl. No.:

8/101491

Inventors:

Durairaj Bommannan - San Francisco CA
Hirohisa Okuyama - San Francisco CA
Richard H. Guy - San Francisco CA
Paul Stauffer - San Rafael CA
Gordon L. Flynn - Ann Arbor MI

Assignee:

Cygnus Therapeutic Systems - Redwood City CA
The Regents of the University of California - Oakland CA

International Classification:

A61B 1700
A16M 3700

US Classification:

601 2

Abstract:

A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.