Paul M Thomas

US Patent:

7792742, Sep 7, 2010

Filed:

Mar 31, 2004

Appl. No.:

10/813260

Inventors:

Paul A. Thomas - Ashburn VA, US
Clifford V. Rossi - Westlake Village CA, US
Robert J. Fishman - Olney MD, US
Martin M. Loketek - Reston VA, US

Assignee:

Federal Home Loan Mortgage Corporation - McLean VA

International Classification:

G06Q 40/00

US Classification:

705 38, 705 35

Abstract:

Embodiments consistent with the present invention provide a credit enhancement structure for risk allocation between parties that minimizes the regulatory capital reserve requirement impact to an institution subject to capital reserve requirement. A subject pool of assets held by the institution, such as a pool of loans, is rated to determine its risk levels. Based on the rated risk levels, a guarantor party agrees to be responsible for a portion of the risk associated with the pool of assets, which may define the maximum risk exposure of the institution holding the asset pool. The risk-rated capital reserve requirements are applied to the asset pool based on the risk level rating and the guarantor's agreed upon risk responsibility such that the institution holds a reduced amount of reserve capital compared to what it would otherwise be required to hold.

US Patent:

7987137, Jul 26, 2011

Filed:

Sep 3, 2010

Appl. No.:

12/875657

Inventors:

Paul A. Thomas - Ashburn VA, US
Clifford V. Rossi - Westlake Village CA, US
Robert J. Fishman - Olney MD, US
Martin M. Loketek - Reston VA, US

Assignee:

Federal Home Loan Mortgage Association - McLean VA

International Classification:

G06Q 40/00

US Classification:

705 38, 705 35, 705 36 R

Abstract:

Embodiments consistent with the present invention provide a credit enhancement structure for risk allocation between parties that minimizes the regulatory capital reserve requirement impact to an institution subject to capital reserve requirement. A subject pool of assets held by the institution, such as a pool of loans, is rated to determine its risk levels. Based on the rated risk levels, a guarantor party agrees to be responsible for a portion of the risk associated with the pool of assets, which may define the maximum risk exposure of the institution holding the asset pool. The risk-rated capital reserve requirements are applied to the asset pool based on the risk level rating and the guarantor's agreed upon risk responsibility such that the institution holds a reduced amount of reserve capital compared to what it would otherwise be required to hold.

US Patent:

8447688, May 21, 2013

Filed:

Jun 30, 2011

Appl. No.:

13/174302

Inventors:

Paul A. Thomas - Ashburn VA, US
Robert J. Fishman - Olney MD, US
Clifford V. Rossi - Westlake Village CA, US
Martin M. Loketek - Reston VA, US

Assignee:

Freddie Mac - McLean VA

International Classification:

G06Q 40/00

US Classification:

705 38, 705 35

Abstract:

Embodiments consistent with the present invention provide a credit enhancement structure for risk allocation between parties that minimizes the regulatory capital reserve requirement impact to an institution subject to capital reserve requirement. A subject pool of assets held by the institution, such as a pool of loans, is rated to determine its risk levels. Based on the rated risk levels, a guarantor party agrees to be responsible for a portion of the risk associated with the pool of assets, which may define the maximum risk exposure of the institution holding the asset pool. The risk-rated capital reserve requirements are applied to the asset pool based on the risk level rating and the guarantor's agreed upon risk responsibility such that the institution holds a reduced amount of reserve capital compared to what it would otherwise be required to hold.

US Patent:

7996304, Aug 9, 2011

Filed:

Sep 3, 2010

Appl. No.:

12/875692

Inventors:

Paul A. Thomas - Ashburn VA, US
Clifford V. Rossi - Westlake Village CA, US
Robert J. Fishman - Olney MD, US
Martin M. Loketek - Reston VA, US

Assignee:

Federal Home Loan Mortgage Corporation - McLean VA

International Classification:

G06Q 40/00

US Classification:

705 38, 705 36 R

Abstract:

Embodiments consistent with the present invention provide a credit enhancement structure for risk allocation between parties that minimizes the regulatory capital reserve requirement impact to an institution subject to capital reserve requirement. A subject pool of assets held by the institution, such as a pool of loans, is rated to determine its risk levels. Based on the rated risk levels, a guarantor party agrees to be responsible for a portion of the risk associated with the pool of assets, which may define the maximum risk exposure of the institution holding the asset pool. The risk-rated capital reserve requirements are applied to the asset pool based on the risk level rating and the guarantor's agreed upon risk responsibility such that the institution holds a reduced amount of reserve capital compared to what it would otherwise be required to hold.

US Patent:

20200048311, Feb 13, 2020

Filed:

Oct 25, 2017

Appl. No.:

16/344772

Inventors:

- Bethesda MD, US
- Bellinzona, CH
Tongqing Zhou - Boyds MD, US
John Mascola - Rockville MD, US
Kai Xu - Bethesda MD, US
Yongping Yang - Potomac MD, US
Paul Thomas - Washington DC, US
Li Ou - Bethesda MD, US
Peter Kwong - Washington DC, US
Yaroslav Tsybovsky - Jefferson MD, US
Wing-Pui Kong - Germantown MD, US
Aliaksandr Druz - Germantown MD, US
Davide Corti - Bellinzona, CH
Antonio Lanzavecchia - Bellinzona, CH

Assignee:

The United States of America, as represented by the Secretary, Dept. of Health and Human Services - Bethesda MD
Institute for Research in Biomedicine - Bellinzona

International Classification:

C07K 14/005
C12N 7/00
A61K 39/155
A61P 31/14

Abstract:

Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

US Patent:

20190330279, Oct 31, 2019

Filed:

Jun 27, 2017

Appl. No.:

16/312166

Inventors:

- Bethesda MD, US
Ivelin Georgiev - Nashville TN, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Aliaksandr Druz - Germantown MD, US
Ulrich Baxa - Frederick MD, US
Joseph Van Galen - North Wales PA, US
Rita Chen - Bethesda MD, US
Cheng Cheng - Rockville MD, US
John Mascola - Rockville MD, US
Yaroslav Tsybovsky - Frederick MD, US
Yongping Yang - Potomac MD, US
Paul Thomas - Washington DC, US
Barney Graham - Rockville MD, US
Syed Mohammad Moin - Bethesda MD, US
Jeffrey Boyington - Clarksburg MD, US
Kizzmekia Corbett - Bethesda MD, US

Assignee:

The United States of America, as represented by the Secretary, Dept. of Health and Human Service - Bethesda MD

International Classification:

C07K 14/11
C07K 14/16
C07K 14/165
C12N 7/00
A61K 39/21
C07K 14/08
C07K 14/435

Abstract:

Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

US Patent:

20190112340, Apr 18, 2019

Filed:

Mar 29, 2017

Appl. No.:

16/089993

Inventors:

- Bethesda MD, US
Barney Graham - Rockville MD, US
John Mascola - Rockville MD, US
Li Ou - Potomac MD, US
Aliaksandr Druz - Germantown MD, US
Man Chen - Bethesda MD, US
Wing-Pui Kong - Germantown MD, US
Ivelin Stefanov Georgiev - Nashville TN, US
Emily Rundlet - New York NY, US
Michael Gordon Joyce - Washington DC, US
Yaroslav Tsybovsky - Frederick MD, US
Paul Thomas - Washington DC, US
Marie Pancera - Seattle WA, US
Mallika Sastry - Rockville MD, US
Cinque Soto - Nashville TN, US
Joseph Van Galen - North Wales PA, US
Guillaume Stewart-Jones - Bethesda MD, US
Yongping Yang - Potomac MD, US
Baoshan Zhang - Bethesda MD, US
Ulrich Baxa - Frederick MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human - Bethesda MD

International Classification:

C07K 14/005
A61P 31/14
A61P 37/04

Abstract:

Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.