Paul R Wiley

US Patent:

42647266, Apr 28, 1981

Filed:

Mar 12, 1980

Appl. No.:

6/129532

Inventors:

Vincent P. Marshall - Portage MI
David W. Elrod - Portage MI
Paul F. Wiley - Portage MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C12P 1946
C12N 114

US Classification:

435 78

Abstract:

Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

47678470, Aug 30, 1988

Filed:

May 11, 1981

Appl. No.:

6/262019

Inventors:

Paul F. Wiley - Kalamazoo MI
David W. Elrod - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07G 1100
C07H 1500
C07H 1700
C07D31902

US Classification:

536 168

Abstract:

The invention concerns a novel nogamycin having a heretofore unknown configuration and novel analogs which are active against various microorganisms. The invention also includes novel methods of making substituted and unsubstituted nogamycin having an essentially pure isomeric form of a preferred configuration.

US Patent:

40778444, Mar 7, 1978

Filed:

Mar 30, 1977

Appl. No.:

5/782621

Inventors:

Vincent P. Marshall - Portage MI
David W. Elrod - Kalamazoo MI
James M. Koert - Kalamazoo MI
Elizabeth A. Reisender - Kalamazoo MI
Paul F. Wiley - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C12D 918

US Classification:

195 80R

Abstract:

Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, there antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

42096111, Jun 24, 1980

Filed:

Apr 6, 1979

Appl. No.:

6/027878

Inventors:

Vincent P. Marshall - Portage MI
David W. Elrod - Portage MI
Paul F. Wiley - Portage MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07H 1524

US Classification:

536 17A

Abstract:

Antibiotics 10-dihydrosteffimycin (U-58,875), and 10-dihydrosteffimycin B (U-58,874) are produced by carbon 10 ketonic carbonyl reduction in fermentation processes using the known antibiotics steffimycin and steffimycin B, respectively, as starting materials. These novel antibiotics are active against various microorganisms, for example, Bacillus subtilis, Bacillus cereus, Sarcina lutea, Streptococcus pyogenes, and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

40862453, Apr 25, 1978

Filed:

Dec 9, 1976

Appl. No.:

5/748716

Inventors:

Paul F. Wiley - Kalamazoo MI
David J. Houser - Portage MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07D31908

US Classification:

2603403

Abstract:

Novel antibiotics, 7-O-alkylnogarols, prepared by acidic alcoholysis of nogamycin, which are active against various microorganisms, for example, Bacillus subtilis and Lactobacillus casei. Thus, they can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

41069943, Aug 15, 1978

Filed:

Nov 16, 1977

Appl. No.:

5/851866

Inventors:

Vincent P. Marshall - Portage MI
David W. Elrod - Kalamazoo MI
James M. Koert - Kalamazoo MI
Elizabeth A. Reisender - Kalamazoo MI
Paul F. Wiley - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C12D 914

US Classification:

195 80R

Abstract:

Bioconversion of the antibiotic steffimycinone to the antibiotic steffimycinol. Steffimycinol is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Streptococcus pyogenes. Steffimycinol is converted to 7-deoxysteffimycinol by a microaerophilic Aeromonas hydrophila fermentation. 7-Deoxysteffimycinol is active against Sarcina lutea, Bacillus cereus, and B. subtilis. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

40643417, Dec 20, 1977

Filed:

Dec 9, 1976

Appl. No.:

5/748718

Inventors:

Paul F. Wiley - Kalamazoo MI
Jian L. Johnson - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C07H 1526

US Classification:

536 17

Abstract:

Novel antibiotic, nogalamycinic acid (U-51,205) prepared by the chemical modification of the known antibiotic nogalamycin. Nogalamycinic acid is active against various microorganisms, for example, Mycobacterium avium, Bacillus subtilis, Lactobacillus casei, Staphylococcus aureus, and Sarcina lutea. Thus, nogalamycinic acid can be used to inhibit the growth of the above microorganisms in various environments.

US Patent:

45058954, Mar 19, 1985

Filed:

Mar 30, 1983

Appl. No.:

6/480604

Inventors:

Alexander D. Argoudelis - Portage MI
Vincent P. Marshall - Kalamazoo MI
Paul F. Wiley - Portage MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

A61K 3574
C12P 106

US Classification:

424117

Abstract:

Novel and useful antibiotics designated 273a. sub. 1. spsb. alpha. and 273a. sub. 1. spsb. beta. can be produced in a fermentation using Streptomyces paulus, strain 273, NRRL 12251. These antibiotics are active against various Gram-positive bacteria. Also, these antibiotics are, advantageously, soluble in aqueous solutions.