Pavel Svoboda

US Patent:

20140004139, Jan 2, 2014

Filed:

Aug 27, 2013

Appl. No.:

14/010668

Inventors:

Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US
Shannon Dalton - Stone Mountain GA, US
Jarad M. Schiffer - Atlanta GA, US

Assignee:

Centers for Disease Control and Prevention - Atlanta GA

International Classification:

C07K 14/32

US Classification:

4241901, 435 792

Abstract:

Regions of protective antigen are provided representing sequences recognized by antibodies in subjects that have vaccine induced lethal toxin neutralizing anti-PA IgG responses. The recognition of these PA regions enhances the utility of anti-PA IgG reactivity as an immune correlate of protection against anthrax in a subject and increases predictive probability of survival. Also provided are vaccines that include at least one of these PA regions that when administered to a subject improve the predictive value of vaccine induced anti-PA IgG and TNA responses as immune correlates of protection against inhalation anthrax.

US Patent:

20120308597, Dec 6, 2012

Filed:

Feb 10, 2011

Appl. No.:

13/577878

Inventors:

Vera A. Semenova - Lilburn GA, US
Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US

Assignee:

Centers for Disease Control and Prevention - Atlanta GA

International Classification:

A61K 39/07
A61P 31/04
G01N 33/566

US Classification:

4241901, 435 792

Abstract:

Regions of protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.

US Patent:

20170165344, Jun 15, 2017

Filed:

Feb 21, 2017

Appl. No.:

15/438152

Inventors:

- Rockville MD, US
Pavel Svoboda - Atlanta GA, US
Jan Pohl - Tucker GA, US
Conrad P. Quinn - Lilburn GA, US

International Classification:

A61K 39/07

Abstract:

Regions of protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.

US Patent:

20150246108, Sep 3, 2015

Filed:

Mar 26, 2015

Appl. No.:

14/669580

Inventors:

- Rockville MD, US
Conrad P. Quinn - Lilburn GA, US
Jan Pohl - Tucker GA, US
Pavel Svoboda - Atlanta GA, US

International Classification:

A61K 39/07

Abstract:

Regions of protective antigen are provided representing epitopes recognized by antibodies in subjects that have acquired immunity to infection. The recognition of these epitopes correlates with autoimmunity in a subject. Also provided are vaccines that include at least one of these epitopes that when administered to a subject provide improved acquired immunity.