Pawan Kumar Dhondi from Solon, OH, age 48

Resumes

Pawan Dhondi

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Us Patents

Gamma Secretase Modulators
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US Patent:

8518975, Aug 27, 2013
Filed:

Sep 4, 2008
Appl. No.:

12/673858
Inventors:

Robert G. Aslanian - Rockaway NJ, US
Xianhai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Jun Qin - Edison NJ, US
Wei Zhou - Scotch Plains NJ, US
Xiaohong Zhu - Edison NJ, US
Pawan Dhondi - Elizabeth NJ, US
William J. Greenlee - Teaneck NJ, US
Assignee:

Merck Sharp + Dohme Corp. - Rahway NJ
International Classification:

C07D 403/12
C07D 401/12
C07D 237/14
A61K 31/501
A61K 31/50
A61K 31/4439
US Classification:

514341, 5462727
Abstract:

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula.

Gamma Secretase Modulators
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US Patent:

20110015190, Jan 20, 2011
Filed:

Dec 4, 2008
Appl. No.:

12/746041
Inventors:

Xianhai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Jun Qin - Somerset NJ, US
Robert Aslanian - Rockaway NJ, US
Zhaoning Zhu - Plainsboro NJ, US
William Greenlee - Teaneck NJ, US
Hubert Josien - Jersey City NJ, US
Wei Zhou - Scotch Plains NJ, US
Xiaohong Zhou - Edison NJ, US
Chad E. Bennett - Metuchen NJ, US
Dmitri Pissarnitski - Scotch Plains NJ, US
Mihirbaran Mandal - Scotch Plains NJ, US
Pawan Dhondi - Elizabeth NJ, US
Troy McCracken - Hoboken NJ, US
Thomas Bara - Linden NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Duane Burnett - Bernardsville NJ, US
John Clader - Cranford NJ, US
International Classification:

A61K 31/5383
C07D 471/04
A61K 31/437
C07D 487/04
A61K 31/519
A61K 31/5377
C07D 498/04
C07D 403/02
A61K 31/4178
A61P 25/28
US Classification:

5142305, 546119, 514303, 546115, 514302, 544263, 5142591, 544118, 5142332, 544105, 5483121, 514397
Abstract:

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein Ris a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

Gamma Secretase Modulators For The Treatment Of Alzheimer's Disease
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US Patent:

20110027264, Feb 3, 2011
Filed:

Feb 26, 2009
Appl. No.:

12/919574
Inventors:

Xianhai Huang - Warren NJ, US
Xianghai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Robert G. Aslanian - Rockaway NJ, US
Zhaoning Zhu - Plainsboro NJ, US
Dmitri A. Pissarnitski - Scotch Plains NJ, US
Hongmei Li - Warren NJ, US
William J. Greenlee - Teaneck NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
Jun Qin - Somerset NJ, US
Pawan Dhondi - Somerset NJ, US
International Classification:

A61K 39/395
C07D 401/12
C07D 221/20
A61K 38/16
A61K 31/454
A61K 31/438
A61P 25/28
US Classification:

4241301, 546210, 546 16, 514 178, 514326, 514278
Abstract:

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

Gamma Secretase Modulators
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US Patent:

20110257156, Oct 20, 2011
Filed:

Nov 5, 2009
Appl. No.:

13/126056
Inventors:

Zhaoning Zhu - Plainsboro NJ, US
William J. Greenlee - Teaneck NJ, US
David James Cole - Springfield NJ, US
Dmitri A. Pissarnitski - Scotch Plains NJ, US
Gioconda V. Gallo - Summit NJ, US
Hongmei Li - Warren NJ, US
Hubert B. Josien - Jersey City NJ, US
Jun Qin - Edison NJ, US
Chad E. Knutson - Garwood NJ, US
Mihirbaran Mandal - Scotch Plains NJ, US
Monica L. Vicarel - North Brunswick NJ, US
Murali Rajagopalan - Edison NJ, US
Pawan Kumar Dhondi - Elizabeth NJ, US
Ruo Xu - Watchung NJ, US
Thomas A. Bara - Linden NJ, US
Xianhai Huang - Warren NJ, US
Xiaohong Zhu - Edison NJ, US
Zhiqiang Zhao - Scotch Plains NJ, US
John W. Clader - Milton VT, US
Anandan Palani - Bridgewater NJ, US
Theodros Asberom - West Orange NJ, US
Troy McCracken - Garwood NJ, US
Chad E. Bennett - Metuchen NJ, US
International Classification:

A61K 31/55
A61K 31/5383
A61K 31/5377
A61K 31/501
A61K 31/497
A61K 31/506
A61K 31/438
A61K 31/437
C07D 413/10
C07D 498/20
C07D 498/04
A61P 25/00
A61P 25/28
A61K 31/4245
A61K 31/5386
US Classification:

51421021, 51421402, 5142295, 5142302, 5142305, 5142332, 51425204, 51425304, 51425505, 514256, 514278, 514302, 514364, 540578, 544 70, 544101, 544105, 544127, 544238, 544333, 544362, 544405, 546 15, 546115, 548131
Abstract:

In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Gamma Secretase Modulators
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US Patent:

20110306593, Dec 15, 2011
Filed:

Nov 11, 2009
Appl. No.:

13/128316
Inventors:

Zhaoning Zhu - Plainsboro NJ, US
William J. Greenlee - Teaneck NJ, US
Hongmei Li - Warren NJ, US
Monica L. Vicarel - North Brunswick NJ, US
Jun Qin - Edison NJ, US
Pawan Kumar Dhondi - Elizabeth NJ, US
Xianhai Huang - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Xiaoxiang Liu - River Vale NJ, US
Hubert B. Josien - Jersey City NJ, US
Ruo Xu - Watchung NJ, US
David James Cole - Springfield NJ, US
Duane A. Burnett - Bernardsville NJ, US
Chad E. Bennett - Metuchen NJ, US
Troy McCracken - Garwood NJ, US
Malcolm MacCoss - Seabrook Island SC, US
International Classification:

A61K 31/553
C07D 498/10
C07D 498/04
A61P 25/28
C07D 413/14
C07D 498/14
A61K 31/5395
C07D 498/20
C07D 413/10
US Classification:

51421108, 544 66, 540545, 5142292
Abstract:

In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compostions.

Quinazolinone-Type Compounds As Crth2 Antagonists
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US Patent:

20130210805, Aug 15, 2013
Filed:

Oct 6, 2011
Appl. No.:

13/878654
Inventors:

Robert G. Aslanian - Rockaway NJ, US
Christopher W. Boyce - Flemington NJ, US
Brian A. McKittrick - New Vernon NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Anandan Palani - Bridgewater NJ, US
Jun Qin - Somerset NJ, US
Haiqun Tang - Belle Mead NJ, US
Dong Xiao - Warren NJ, US
Younong Yu - East Brunswick NJ, US
John P. Caldwell - Ringwood NJ, US
Elizabeth Helen Kelley - Lynnfield MA, US
Hongjun Zhang - Newton MA, US
Phieng Siliphaivanh - Newton MA, US
Rachel N. MacCoss - Oxford, GB
Joey L. Methot - Westwood MA, US
Jolicia Polivina Gauuan - Schenectady NY, US
Qin Jiang - Latham NY, US
Andrew J. Leyhane - Latham NY, US
Johny Biju - Piscataway NJ, US
Li Dong - Lawrenceville NJ, US
Xian Huang - Warren NJ, US
Ning Shao - Watchung NJ, US
Wei Zhou - Scotch Plains NJ, US
Pawan K. Dhondi - Elizabeth NJ, US
International Classification:

C07D 239/91
A61K 31/517
A61K 45/06
C07D 403/10
C07D 417/10
C07D 413/10
C07D 405/10
C07D 413/14
C07D 498/10
C07D 403/14
A61K 31/55
C07D 401/14
A61K 31/5395
C07D 471/04
C07D 401/10
US Classification:

51421207, 544284, 51426621, 5142662, 51426623, 544290, 51426624, 5142663, 544230, 540523, 514249, 544 66, 5142292, 51426622
Abstract:

This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTHreceptor.

Quinoxalines And Aza-Quinoxalines As Crth2 Receptor Modulators
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US Patent:

20130303517, Nov 14, 2013
Filed:

Dec 19, 2011
Appl. No.:

13/996361
Inventors:

Christopher W. Boyce - Flemington NJ, US
Sylvia Joanna Degrado - Scotch Plains NJ, US
Xiao Chen - Edison NJ, US
Jun Qin - Edison NJ, US
Younong Yu - East Brunswick NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Anandan Palani - Bridgewater NJ, US
Dong Xiao - Warren NJ, US
Robert George Aslanian - Rockaway NJ, US
Jie Wu - Scotch Plains NJ, US
Ashwin Umesh Rao - Morganville NJ, US
Phieng Siliphaivanh - Newton MA, US
Joey L. Methot - Westwood MA, US
Hongjun Zhang - Newton MA, US
Elizabeth Helen Kelley - Lynnfield MA, US
William Colby Brown - Cleveland Heights OH, US
Qin Jiang - Latham NY, US
Jolicia Polivina Gauuan - Schenectady NY, US
Andrew J. Leyhane - Latham NY, US
Purakkattle Johny Biju - Piscataway NJ, US
Pawan K. Dhondi - Elizabeth NJ, US
Li Dong - Lawrenceville NJ, US
Salem Fevrier - Cranford NJ, US
Xianhai Huang - Warren NJ, US
Henry M. Vaccaro - South Plainfield NJ, US
International Classification:

C07D 241/42
C07D 401/12
C07D 403/06
C07D 471/04
A61K 31/4985
C07D 471/10
C07D 405/12
C07D 401/14
A61K 31/506
A61K 31/55
C07D 417/12
C07D 498/04
C07D 491/107
A61K 45/06
A61K 31/498
US Classification:

51421018, 544353, 514249, 544350, 544230, 51421021, 544295, 540523, 51421207
Abstract:

The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J, J, R, R, R, R, R, R, R, R, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTHfunction.

Antidiabetic Tricyclic Compounds
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US Patent:

20160257652, Sep 8, 2016
Filed:

Nov 10, 2014
Appl. No.:

15/032191
Inventors:

- Rahway NJ, US
Purakkattle Biju - Westwood MA, US
Steven L. Colletti - Princeton NJ, US
Qun Dang - Westfield NJ, US
Pawan Dhondi - Elizabeth NJ, US
Candido Gude - Staten Island NY, US
Hubert Josien - Jersey City NJ, US
Nam Fung Kar - Brooklyn NY, US
Anilkumar G. Nair - Edison NJ, US
Ravi P. Nargund - East Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Cheng Zhu - Edison NJ, US
International Classification:

C07D 221/16
A61K 9/20
A61K 31/435
A61K 31/444
C07D 401/12
A61K 31/4545
C07D 487/04
A61K 45/06
C07D 487/10
Abstract:

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.