Pedro Eduardo Valencia

US Patent:

20160022835, Jan 28, 2016

Filed:

Mar 17, 2014

Appl. No.:

14/777304

Inventors:

- Boston, MA, US
- Cambridge, MA, US
- New York, NY, US
Nazila Kamaly - Boston MA, US
Mingming Ma - Boston MA, US
Pedro M. Valencia - Miami FL, US
Robert S. Langer - Newton MA, US
Ira Tabas - New York NY, US
Gabrielle Beth Fredman - New York NY, US

International Classification:

A61K 47/48
A61K 31/195
A61K 38/16

Abstract:

Sub-100 micron multimodal nanoparticles have four main components: 1) a target element (peptides, lipids, antibodies, small molecules, etc.) that can selectively bind to cells, tissues, or organs of the body; 2) a diagnostic agent such as a fluorophore or NMR contrast agent that allows visualization of nanoparticles at the site of delivery and/or a therapeutic or prophylactic agent; 3) an outside “stealth” layer that allows the particles to evade recognition by immune system components and increase particle circulation half-life; and 4) a biodegradable polymeric material, forming an inner core which can carry therapeutics and release the payloads at a sustained rate after systemic, intraperitoneal, or mucosal administration. These particles possess excellent stability, high loading efficiency, multiple agent encapsulation, targeting and imaging. They are targeted to sites of, or associated with, inflammation caused by a disease, disorder; trauma, chemotherapy or radiation.