Pei J Han

US Patent:

20130109738, May 2, 2013

Filed:

Feb 23, 2011

Appl. No.:

13/580122

Inventors:

Calvin Hang - Stanford CA, US
Pei Han - Mountain View CA, US
Jin Yang - Mountain View CA, US
Ksiu-Ling Cheng - Taipei, TW

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 31/7088
A61K 31/138
G01N 33/68

US Classification:

514 44 A, 435 71, 800 3, 800 9, 435375, 514651

Abstract:

Methods and compositions are provided for the diagnosis and treatment of heart diseases relating to cardiac hypertrophy, and for the regulation of proliferation and differentiation of cardiomyocyte progenitors in vitro. The detection of expression of components of the BAF complex, including, without limitation, detection of expression of Brg1, provides useful methods for early detection, diagnosis, staging, and monitoring of conditions leading to hypertrophy and enlargement of the heart. Manipulation of Brg1 activity provides for therapeutic intervention in the development of cardiac hypertrophy, where methods of decreasing Brg1 activity, e.g. through inhibition of binding, decreasing expression, and the like, reduces cardiac hypertrophy.