Pei Yu

US Patent:

6391582, May 21, 2002

Filed:

Dec 9, 1998

Appl. No.:

09/208827

Inventors:

Ying Luo - Los Altos CA
Pei Wen Yu - Burlingame CA
James Lorens - Portola Valley CA

Assignee:

Rigel Pharmaceuticlas, Inc. - So. San Francisco CA

International Classification:

C12P 2102

US Classification:

435 691, 435466, 435477, 435483

Abstract:

The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provided is a method wherein yeast are transformed with a shuttle vector as provided herein. Heterologous nucleic acids flanked by 5â and 3â ends identical to a homologous recombination site within the shuttle vector are introduced to the transformed yeast and allowed to homologously recombine with the shuttle vector such that they are inserted into the vector by the yeast organism. The shuttle vector is then recovered and transferred to a mammalian cell for expression.

US Patent:

6645766, Nov 11, 2003

Filed:

Jan 7, 2002

Appl. No.:

10/043074

Inventors:

Ying Luo - Los Altos CA
Pei Wen Yu - Burlingame CA
James Lorens - Portola Valley CA

Assignee:

Rigel Pharmaceuticals, Inc. - San Francisco CA

International Classification:

C12N 1564

US Classification:

435466, 435477, 435483, 4353201, 43525421

Abstract:

The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provided is a method wherein yeast are transformed with a shuttle vector as provided herein. Heterologous nucleic acids flanked by 5â and 3â ends identical to a homologous recombination site within the shuttle vector are introduced to the transformed yeast and allowed to homologously recombine with the shuttle vector such that they are inserted into the vector by the yeast organism. The shuttle vector is then recovered and transferred to a mammalian cell for expression.

US Patent:

7223850, May 29, 2007

Filed:

Aug 6, 1999

Appl. No.:

09/762491

Inventors:

Ying Luo - Los Altos CA, US
Betty Huang - San Leandro CA, US
Mary Shen - Newark CA, US
Pei Wen Yu - Cupertino CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 15/11
C07K 14/00

US Classification:

536 231, 4353201, 435 4, 435 6, 530350

Abstract:

The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

7488805, Feb 10, 2009

Filed:

Apr 24, 2007

Appl. No.:

11/739267

Inventors:

Ying Luo - Los Altos CA, US
Betty Huang - San Leandro CA, US
Mary Shen - Newark CA, US
Pei Wen Yu - Cupertino CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07K 16/00

US Classification:

53038815, 5303871, 5303879

Abstract:

The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

20060228761, Oct 12, 2006

Filed:

Dec 6, 2005

Appl. No.:

11/295841

Inventors:

Ying Luo - Shanghai, CN
Pei Yu - Cupertino CA, US
Mary Shen - Newark CA, US
Betty Huang - San Leandro CA, US

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

G01N 33/574
C07H 21/04
C12P 21/06
C40B 30/06
C07K 14/82
C07K 16/30

US Classification:

435007230, 435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

62809377, Aug 28, 2001

Filed:

Aug 14, 1998

Appl. No.:

9/133944

Inventors:

Ying Luo - Los Altos CA
Pei Wen Yu - Burlingame CA
James Lorens - Portola Valley CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provided is a method wherein yeast are transformed with a shuttle vector as provided herein. Heterologous nucleic acids flanked by 5' and 3' ends identical to a homologous recombination site within the shuttle vector are introduced to the transformed yeast and allowed to homologously recombine with the shuttle vector such that they are inserted into the vector by the yeast organism. The shuttle vector is then recovered and transferred to a mammalian cell for expression.

US Patent:

20230036402, Feb 2, 2023

Filed:

Jul 22, 2021

Appl. No.:

17/383362

Inventors:

- Redmond WA, US
Zicheng LIU - Bellevue WA, US
Ying JIN - Kirkland WA, US
Hongli DENG - Bellevue WA, US
Kun LUO - Redmond WA, US
Pei YU - Bellevue WA, US
Yinpeng CHEN - Sammamish WA, US

International Classification:

G06K 9/20
G06K 9/00
G06T 7/70

Abstract:

To improve the accuracy and efficiency of object detection through computer digital image analysis, the detection of some objects can inform the sub-portion of the digital image to which subsequent computer digital image analysis is directed to detect other objects. In such a manner object detection can be made more efficient by limiting the image area of a digital image that is analyzed. Such efficiencies can represent both computational efficiencies and communicational efficiencies arising due to the smaller quantity of digital image data that is analyzed. Additionally, the detection of some objects can render the detection of other objects more accurate by adjusting confidence thresholds based on the detection of those related objects. Relationships between objects can be utilized to inform both the image area on which subsequent object detection is performed and the confidence level of such subsequent object detection.

US Patent:

20200211052, Jul 2, 2020

Filed:

Dec 31, 2018

Appl. No.:

16/237581

Inventors:

- Redmond WA, US
Christopher D. Erbach - Palo Alto CA, US
Pei Qun Yu - Sunnyvale CA, US
Nirav Nalinbhai Shingala - Santa Clara CA, US
Alexandros Ntoulas - Sunnyvale CA, US
Rohan Rajiv - Santa Clara CA, US

International Classification:

G06Q 30/02
G06N 20/00

Abstract:

Techniques for optimizing content item delivery for installations or activations of a mobile application are provided. In one technique, a machine-learned model is trained based on multiple training instances that individually indicate whether an entity performed a particular action relative to a mobile application. In response to receiving a content item request from a third-party content delivery exchange, it is determined whether a client device that initiated the content item request has activated a particular application. In response to determining that the client device has not activated the particular application, multiple feature values of the content item request are identified. Based on inputting the feature values into the model, a score is generated that indicates a likelihood that an entity of the client device will perform the particular action relative to the particular application. Based on the score, a content item is transmitted over a network to the client device.