Peng Zheng

US Patent:

6556850, Apr 29, 2003

Filed:

Sep 15, 2000

Appl. No.:

09/663071

Inventors:

James R. Braig - Alameda CA
Charles E. Kramer - Poway CA
Bernhard B. Sterling - Danville CA
Daniel S. Goldberger - Boulder CO
Peng Zheng - Alameda CA
Arthur M. Shulenberger - Brisbane CA
Rick Trebino - Atlanta GA
Richard A. King - Berkeley CA
Casper W. Barnes - Murrieta CA

Assignee:

Optiscan Biomedical Corporation - Alameda CA

International Classification:

A61B 500

US Classification:

600310, 600322, 25033903, 25033907, 2503416

Abstract:

A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

US Patent:

6577885, Jun 10, 2003

Filed:

Sep 15, 2000

Appl. No.:

09/663114

Inventors:

James R. Braig - Alameda CA
Charles E. Kramer - Poway CA
Bernhard B. Sterling - Danville CA
Daniel S. Goldberger - Boulder CO
Peng Zheng - Alameda CA
Arthur M. Shulenberger - Brisbane CA
Rick Trebino - Atlanta GA
Richard A. King - Berkeley CA
Casper W. Barnes - Murrieta CA

Assignee:

OptiScan Biomedical Corporation - Alameda CA

International Classification:

A61B 500

US Classification:

600310, 600322, 25033903, 25033907, 2503416

Abstract:

A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

US Patent:

6580934, Jun 17, 2003

Filed:

Mar 30, 2000

Appl. No.:

09/538164

Inventors:

James R. Braig - Piedmont CA
Charles E. Kramer - Poway CA
Bernhard B. Sterling - Danville CA
Daniel S. Goldberger - Boulder CO
Peng Zheng - Alameda CA
Arthur M. Shulenberger - Brisbane CA
Richard A. King - Berkeley CA
Casper W. Barnes - Murrieta CA

Assignee:

Optiscan Biomedical Corporation - Alameda CA

International Classification:

A61B 500

US Classification:

600310, 600322, 25033903, 25033907, 2503416

Abstract:

A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample.

US Patent:

6731961, May 4, 2004

Filed:

Nov 8, 2002

Appl. No.:

10/291912

Inventors:

James R. Braig - Piedmont CA
W. Dale Hall - Oakland CA
Casper W. Barnes - Murrieta CA
Peng Zheng - Alameda CA
Jennifer H. Gable - Walnut Creek CA

Assignee:

OptiScan Biomedical Corp. - Alameda CA

International Classification:

A61B 500

US Classification:

600310, 600322, 25033907, 2503416

Abstract:

A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. One embodiment provides a transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation. Phase and magnitude differences in the transfer function are detected in the presence of the sought-after analyte. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. Another embodiment provides a method for transforming thermal phase spectra to absorption spectra for consistent determination of analyte concentration within the sample.

US Patent:

6825044, Nov 30, 2004

Filed:

Nov 21, 2002

Appl. No.:

10/301927

Inventors:

Peng Zheng - Alameda CA
Jennifer H. Gable - Walnut Creek CA
W. Dale Hall - Oakland CA
Kenneth G. Witte - San Jose CA
James R. Braig - Piedmont CA

Assignee:

Optiscan Biomedical Corporation - Alameda CA

International Classification:

G01N 2164

US Classification:

436164, 436172, 422 8205, 422 8207

Abstract:

A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined.

US Patent:

6917038, Jul 12, 2005

Filed:

Nov 21, 2002

Appl. No.:

10/302030

Inventors:

Peng Zheng - Alameda CA, US
Jennifer H. Gable - Walnut Creek CA, US
W. Dale Hall - Oakland CA, US
Kenneth G. Witte - San Jose CA, US
James R. Braig - Piedmont CA, US

Assignee:

Optiscan Biomedical Corporation - Alameda CA

International Classification:

G01H005/02

US Classification:

25033904, 25033901, 2503381, 2503361

Abstract:

An analyte detection system non-invasively determines the concentration of an analyte in a sample generating a sample infrared signal indicative of the concentration of the analyte in the sample. The detection system includes a window assembly for receiving the sample infrared signal. The window assembly is adapted to allow the sample infrared signal to transmit therethrough, and generates a window infrared signal. The detection system further includes at least one detector configured to receive both the window infrared signal and the sample infrared signal transmitted through the window assembly. The detector is further adapted to generate a detector signal in response thereto. The detection system further includes a correction module configured to generate a corrected detector signal indicative of the concentration of the analyte in the sample.

US Patent:

6944486, Sep 13, 2005

Filed:

Jun 6, 2003

Appl. No.:

10/456109

Inventors:

James R. Braig - Piedmont CA, US
Charles E. Kramer - Poway CA, US
Bernhard B. Sterling - Danville CA, US
Daniel S. Goldberger - Boulder CO, US
Peng Zheng - Alameda CA, US
Arthur M. Shulenberger - Brisbane CA, US
Richard A. King - Berkeley CA, US
Casper W. Barnes - Murrieta CA, US

Assignee:

Optiscan Biomedical Corporation - Alameda CA

International Classification:

A61B005/00

US Classification:

600310, 600322, 25033903, 25033907, 2503416

Abstract:

A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced into the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the sample.

US Patent:

7006857, Feb 28, 2006

Filed:

Apr 28, 2003

Appl. No.:

10/426160

Inventors:

James R. Braig - Alameda CA, US
Charles E. Kramer - Poway CA, US
Bernhard B. Sterling - Danville CA, US
Daniel S. Goldberger - Boulder CO, US
Peng Zheng - Alameda CA, US
Arthur M. Shulenberger - Brisbane CA, US
Rick Trebino - Atlanta GA, US
Richard A. King - Berkeley CA, US
Casper W. Barnes - Murrieta CA, US

Assignee:

OptiScan Biomedical Corporation - Alameda CA

International Classification:

A61B 5/00
G01N 21/71

US Classification:

600310, 600322, 25033903, 25033907, 2503416

Abstract:

A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.