Penghui Chen

US Patent:

20030186970, Oct 2, 2003

Filed:

Sep 9, 2002

Appl. No.:

10/238363

Inventors:

Robert Higuchi - Solana Beach CA, US
Kristen Arienti - San Diego CA, US
Mani Neelakandha - San Diego CA, US
Barbara Pio - San Diego CA, US
Lin Zhi - San Diego CA, US
Penghui Chen - San Diego CA, US
Thomas Caferro - San Diego CA, US

International Classification:

A61K031/54
A61K031/538
A61K031/498
A61K031/4745

US Classification:

514/224200, 514/229800, 514/250000, 514/292000, 544/032000, 544/101000, 544/345000, 546/080000

Abstract:

Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

US Patent:

20070167445, Jul 19, 2007

Filed:

Jan 25, 2006

Appl. No.:

11/340282

Inventors:

Robert Higuchi - Solana Beach CA, US
Kristen Arienti - La Mesa CA, US
Neelakandha Mani - San Diego CA, US
Barbara Pio - Hillsborough NJ, US
Lin Zhi - San Diego CA, US
Penghui Chen - Wilmington DE, US
Thomas Caferro - Holly Springs NC, US

International Classification:

A61K 31/538
A61K 31/498

US Classification:

514230500, 514249000, 544105000, 544353000

Abstract:

Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.

US Patent:

6462038, Oct 8, 2002

Filed:

Aug 25, 2000

Appl. No.:

09/648684

Inventors:

Robert Higuchi - Solana Beach CA
Kristen L. Arienti - San Diego CA
Mani Neelakandha - San Diego CA
Barbara Pio - San Diego CA
Lin Zhi - San Diego CA
Penghui Chen - San Diego CA
Thomas R. Caferro - San Diego CA

Assignee:

Ligand Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31536

US Classification:

5142245, 5142298, 514250, 514291, 544 34, 544101, 544345, 546 80, 546 89, 546 90

Abstract:

Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions that are agonists, partial agonists, and antagonists for the androgen receptor (AR) are described. Further, described are the methods of making and use of critical intermediates including a stereoselective synthetic route to intermediates for the AR modulators.