Percy Minden

US Patent:

46893970, Aug 25, 1987

Filed:

Aug 12, 1985

Appl. No.:

6/765048

Inventors:

Thomas M. Shinnick - Del Mar CA
Percy Minden - La Jolla CA
Richard A. Houghten - Solana Beach CA

Assignee:

Scripps Clinic and Research Foundation - La Jolla CA

International Classification:

C07C 708
C07C 710

US Classification:

530327

Abstract:

Antigens, immunogens, inocula, antibodies, diagnostic methods and systems relating to tuberculous mycobacteria are disclosed. Each of the compounds, compositions, methods or systems contains a synthetic polypeptide having about 13 or 14 to about 40 residues, or an antibody containing site that immunoreacts with such a polypeptide. The polypeptide includes the thirteen or fourteen amino acid reside sequence (AlaLysValAsnIleLysProLeuGluAspLysIleCys) or (CysAlaLysValAsnIleLysProLeuGluAspLysIleCys). When linked to a carrier and introduced in an effective amount into a mammalian host, the polypeptide is capable of inducing production of antibodies that immunoreact with an antigen to a tuberculous mycobacterium.