Peter K Davis

US Patent:

6359061, Mar 19, 2002

Filed:

Mar 19, 1999

Appl. No.:

09/272106

Inventors:

Eric Edward Swayze - Carlsbad CA
Peter William Davis - Encinitas CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07D21172

US Classification:

525 5411, 514579, 546316, 548228, 548229, 5483164, 5483361, 5483381, 5483385, 548477, 548497, 558390, 558430, 558438, 558442, 540148, 540158, 564 1, 564 50, 564105, 544358

Abstract:

Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds.

US Patent:

6448373, Sep 10, 2002

Filed:

Jan 11, 1994

Appl. No.:

08/179970

Inventors:

Phillip D. Cook - Carlsbad CA
Oscar L. Acevedo - San Diego CA
Peter W. Davis - Carlsbad CA
David J. Ecker - Leucadia CA
Normand Herbert - San Marcos CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 3800

US Classification:

530300, 435 6, 436501, 514 2, 514 44, 536 221, 530323, 530332, 530333

Abstract:

Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

US Patent:

6558633, May 6, 2003

Filed:

Sep 21, 1994

Appl. No.:

08/309925

Inventors:

David J. Ecker - Leucadia CA
Oscar Acevedo - San Diego CA
Normand Hebert - Cardiff CA
Peter W. Davis - Carlsbad CA
Jacqueline R. Wyatt - Carlsbad CA
John S. Kiely - San Diego CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C12M 118

US Classification:

422134, 422 50, 422131, 4352885, 4352884, 4353052

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

6750344, Jun 15, 2004

Filed:

Sep 5, 1997

Appl. No.:

08/924851

Inventors:

Eric Edward Swayze - Carlsbad CA
Peter William Davis - Encinitas CA
Robert Jay Tinder - La Jolla CA
Kelly G. Sprankle - Vista CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07D24136

US Classification:

544355, 544338, 544336, 544349, 435 4, 435 71, 436501, 436518, 436536

Abstract:

The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized to form bicyclic amine scaffolds. These can then be reacted with building blocks to form the amine compounds of the invention. This invention further provides libraries or monocyclic, bicyclic and oligomeric amine compounds. Also provided are methods for preparing monocyclic, bicyclic and oligomeric amine compounds and libraries thereof. The present invention also provides pharmaceutical compositions of the monocyclic, bicyclic and oligomeric amine compounds.

US Patent:

20010028866, Oct 11, 2001

Filed:

May 23, 2001

Appl. No.:

09/863158

Inventors:

David Ecker - Leucadia CA, US
Oscar Acevedo - San Diego CA, US
Normand Hebert - Cardiff CA, US
Peter Davis - Carlsbad CA, US
Jacqueline Wyatt - Carlsbad CA, US
John Kiely - San Diego CA, US

Assignee:

ISIS Pharmaceuticals, Inc.

International Classification:

B01J019/00

US Classification:

422/131000

Abstract:

Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical droplet generation and direction techniques are employed to prepare oligomers and libraries of chemical species. Reaction assemblies adapted for efficient synthetic employment and for improved collection are also disclosed.

US Patent:

20030065146, Apr 3, 2003

Filed:

Jun 3, 2002

Appl. No.:

10/162365

Inventors:

Phillip Cook - Carlsbad CA, US
Oscar Acevedo - San Diego CA, US
Peter Davis - Carlsbad CA, US
David Ecker - Leucadia CA, US
Normand Hebert - San Marcos CA, US

International Classification:

C07K014/00
C07F009/6512

US Classification:

530/350000, 544/243000, 544/244000, 525/054500

Abstract:

Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

US Patent:

55874711, Dec 24, 1996

Filed:

Jan 11, 1994

Appl. No.:

8/179972

Inventors:

Phillip D. Cook - Carlsbad CA
David J. Ecker - Encinitas CA
Oscar L. Acevedo - San Diego CA
Peter Davis - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2100

US Classification:

536 253

Abstract:

The present invention provides methods of analyzing and evaluating phosphorus bearing monomeric units as to their suitability for use in preparing randomer oligomer libraries. The invention further provides methods for preparing such randomer oligomer libraries from the selected monomers.

US Patent:

51682940, Dec 1, 1992

Filed:

Sep 27, 1991

Appl. No.:

7/769159

Inventors:

Peter H. Davis - Dallas TX
Brad V. Christensen - Plano TX
Robert R. Ahlfinger - Waxahachie TX

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

G09B 2302
G03B 2114

US Classification:

353122

Abstract:

A calculator (20) or other computing device uses a remote display (22) set upon an elevated platform (26) above the base (12) of an overhead projector (10). Light through the base lens (14) is passed through the display (22) and is enlarged by lens (30).