Peter M Howley

US Patent:

6399075, Jun 4, 2002

Filed:

Jul 2, 1999

Appl. No.:

09/347504

Inventors:

Peter M. Howley - Wellesley MA
John Benson - Brookline MA
Hiroaki Kasukawa - Princeton NJ

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 3912

US Classification:

4242041, 514 12, 530350, 530321, 530325, 530326, 5303884, 536 2374

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

6432926, Aug 13, 2002

Filed:

Jul 27, 1999

Appl. No.:

09/362012

Inventors:

Peter M. Howley - Wellesley MA
John D. Benson - Brookline MA
Hiroyuki Sakai - Kyoto, JP

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 4800

US Classification:

514 44, 514 12, 536 231, 435325, 435455, 4242041

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

6673354, Jan 6, 2004

Filed:

Jun 3, 2002

Appl. No.:

10/161499

Inventors:

Peter M. Howley - Wellesley MA
John Benson - Brookline MA
Hiroaki Kasukawa - Princeton NJ

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 3912

US Classification:

4242041, 514 12, 530350, 530321, 530325, 530326, 5303884, 536 2374

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

7223556, May 29, 2007

Filed:

Oct 8, 1999

Appl. No.:

09/415795

Inventors:

Pengbo Zhou - New York NY, US
Peter M. Howley - Wellesley MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12P 21/06
C12N 9/00
C12N 5/16
C12N 5/18
C12N 5/22
C07H 21/04

US Classification:

435 681, 435 697, 435183, 435325, 435354, 435366, 435375, 536 234

Abstract:

The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.

US Patent:

7235244, Jun 26, 2007

Filed:

Dec 23, 2003

Appl. No.:

10/744964

Inventors:

Peter M. Howley - Wellesley MA, US
John Benson - Brookline MA, US
Hiroaki Kasukawa - Princeton NJ, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/12

US Classification:

4242041, 530300, 435 691

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

7423138, Sep 9, 2008

Filed:

Jul 1, 2002

Appl. No.:

10/187536

Inventors:

Peter M. Howley - Wellesley MA, US
John D. Benson - Brookline MA, US
Hiroyuki Sakai - Kyoto, JP

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 39/12

US Classification:

536 2372, 4242041

Abstract:

By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2protein, either directly or by gene transfer techniques, to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.

US Patent:

20050123902, Jun 9, 2005

Filed:

May 21, 2004

Appl. No.:

10/851407

Inventors:

Patricio Meneses - Philadelphia PA, US
Angela Koehler - Cambridge MA, US
Jason Wong - Oberlin OH, US
Peter Howley - Wellesley MA, US
Stuart Schreiber - Boston MA, US

International Classification:

C12Q001/70
A61K031/41
C07K007/08

US Classification:

435005000, 530326000, 514381000

Abstract:

The present invention provides systems for identifying anti-viral agents. In particular, the invention encompasses reagents and strategies for identifying agents that inhibit or disrupt key protein-protein interactions that are important in the life cycle of papillomaviruses. The invention allows identification, production, and/or use of agents that reduce or inhibit the replication of HPV by inhibiting (e.g., precluding, reversing, or disrupting) the formation of the E1-E2 protein-protein complex. The invention also provides specific inhibitory agents, pharmaceutical compositions, and methods of using these inhibitors and pharmaceutical compositions for inhibiting viral replication in vitro. Methods are also described for the treatment and prevention of HPV infections and HPV-related diseases in patients.

US Patent:

20060223055, Oct 5, 2006

Filed:

Dec 29, 2005

Appl. No.:

11/322164

Inventors:

Peter Howley - Wellesley MA, US
Jianxin You - Brookline MA, US

International Classification:

C12Q 1/70
C07H 21/04
C07K 14/03
C07K 16/08
C12N 15/86

US Classification:

435005000, 435069300, 435325000, 435456000, 530350000, 530388300, 536023720

Abstract:

The present invention relates to methods and compositions for the treatment and/or prevention of diseases or disorders associated with viral infection. Accordingly, the nucleotide and amino acid sequences for a human Brd4 protein are provided. Also provided are complexes comprising Brd4 and an E2 protein or a functional equivalent of an E2 protein.