Peter Guang Lu

US Patent:

6565848, May 20, 2003

Filed:

Apr 11, 2000

Appl. No.:

09/546934

Inventors:

Peter S. Lu - Mountain View CA
Mark M. Davis - Atherton CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 39395

US Classification:

4241391, 4241541, 4241531, 435377

Abstract:

The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical cadherin characteristics, but it exhibits an apical distribution pattern on the surface of lymphocytes. The membrane location of this molecule correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.

US Patent:

6942981, Sep 13, 2005

Filed:

Oct 13, 2000

Appl. No.:

09/688017

Inventors:

Peter S. Lu - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Johannes Schweizer - Mountain View CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

G01N033/53

US Classification:

435 71

Abstract:

Methods are provided for determining interactions between multiple PDZ-domain polypeptides and PDZ Ligand Proteins.

US Patent:

7312041, Dec 25, 2007

Filed:

Jul 29, 2003

Appl. No.:

10/630590

Inventors:

Peter S. Lu - Mountain View CA, US
Johannes Schweizer - Mountain View CA, US
Chamorro Somoza Diaz-Sarmiento - Palo Alto CA, US
Michael P. Belmares - San Jose CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

C12Q 1/00
C12Q 1/70
G01N 33/53

US Classification:

435 71, 435 4, 435 5, 435 79, 435 792, 435 794, 4242041

Abstract:

The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human E6 proteins in clinical samples.

US Patent:

7312071, Dec 25, 2007

Filed:

Dec 6, 2002

Appl. No.:

10/313354

Inventors:

Peter S. Lu - Mountain View CA, US
Thomas M. Sherlock - Los Altos CA, US
Joseph Byerly - Pebble Beach CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

C12M 1/34

US Classification:

4352876, 4352874, 435808, 4352883, 4352885, 73 6163, 7386323

Abstract:

A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e. g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

US Patent:

7399467, Jul 15, 2008

Filed:

Dec 23, 2004

Appl. No.:

11/021949

Inventors:

Peter S. Lu - Palo Alto CA, US
Jonathan David Garman - San Jose CA, US
Michael P. Belmares - San Jose CA, US
Chamorro Somoza Diaz-Sarmiento - Mountain View CA, US
Johannes Schweizer - Mountain View CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

A61K 39/395

US Classification:

4241301, 435345

Abstract:

The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.

US Patent:

7432065, Oct 7, 2008

Filed:

May 16, 2005

Appl. No.:

11/131054

Inventors:

Peter S. Lu - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Johannes Schweizer - Mountain View CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.

US Patent:

7459308, Dec 2, 2008

Filed:

Sep 15, 2003

Appl. No.:

10/663538

Inventors:

Peter S. Lu - Mountain View CA, US
Jonathan David Garman - San Jose CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

C07K 14/435
C07H 21/04
C12P 21/02
C12N 1/16
C12N 1/20
C12N 5/06
C12N 15/09

US Classification:

435325, 435 691, 435 701, 4352523, 4353201, 536 231, 536 235, 530350

Abstract:

The present invention relates to a cell surface molecules, designated cadherin-like asymmetry proteins (“CLASPs”). In particular, it relates to CLASP-2 polynucleotides, polypeptides, fusion proteins, and antibodies. The invention also relates to methods of modulating an immune response by interfering with CLASP function.

US Patent:

7514224, Apr 7, 2009

Filed:

May 16, 2005

Appl. No.:

11/131042

Inventors:

Peter S. Lu - Mountain View CA, US
Joshua D. Rabinowitz - Mountain View CA, US
Johannes Schweizer - Mountain View CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

G01N 33/53
C07K 14/00

US Classification:

435 71, 530350, 436809

Abstract:

The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.