Peter A Mcdonnell

US Patent:

5418225, May 23, 1995

Filed:

Jan 5, 1993

Appl. No.:

8/000935

Inventors:

Jonathan C. Javitt - Washington DC
Norman B. Javitt - New York NY
Peter McDonnell - Los Angeles CA

International Classification:

A61K 31715
A61K 3170

US Classification:

514 58

Abstract:

A topical composition comprising an amount of a carbonic anhydrase inhibitor and an amount of. beta. -cyclodextrin derivative effective in increasing the bioavailability of the carbonic anhydrase inhibitor when coadministered topically to the eye.

US Patent:

7336989, Feb 26, 2008

Filed:

Apr 3, 2003

Appl. No.:

10/407848

Inventors:

Roy S. Chuck - Irvine CA, US
Peter J. McDonnell - Irvine CA, US
Ramez Emile Necola Shehada - La Mirada CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 6/00

US Classification:

600477, 600407, 600476

Abstract:

Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e. g. , laser pulse(s), preferably in the ultraviolet region (e. g. 193-nm)), is directed onto the material to ablate a thin layer of the material using photochemical decomposition. Simultaneously, the laser energy induces fluorescence of the substance(s) within the ablated layer of the material. The fluorescence emitted by the substance(s) is then received by a device, which measures the spectrum of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

US Patent:

60333960, Mar 7, 2000

Filed:

Nov 6, 1996

Appl. No.:

8/744936

Inventors:

David Huang - South Pasadena CA
Peter J. McDonnell - La Canada CA

International Classification:

A61N 502

US Classification:

606 5

Abstract:

Noncontact apparatus and method for preforming laser thermal keratoplasty capable of scanning of treatment areas with shapes that reduce regression. The apparatus includes laser sources, a projection optical system, observation system, and control system The projection system uses two steering mirrors to control laser beam position on the cornea. This projection system enables precise control of the area of corneal heat shrinkage using relatively low-powered lasers, such as diode lasers. Desired changes in corneal refractive power are produced by selected patterns of photothermal shrinkage of corneal collagen tissue. The selected patterns are arrangements of oblong shapes that are preferably tapered at the ends of the long axis. The oblong shape and tapering distribute tension in the cornea over a wider area of collagen shrinkage and improve the stability of refractive correction. The long axes of the oblong treatment areas are preferably oriented radially for hyperopia correction and circumferentially for astigmatism correction.

US Patent:

54949017, Feb 27, 1996

Filed:

Jan 5, 1993

Appl. No.:

8/000935

Inventors:

Jonathan C. Javitt - Washington DC
Norman B. Javitt - New York NY
Peter McDonnell - Los Angeles CA

International Classification:

A61K 31715
A61K 3170

US Classification:

514 58

Abstract:

A topical composition comprising an amount of a carbonic anhydrase inhibitor and an amount of. beta. -cyclodextrin derivative effective in increasing the bioavailability of the carbonic anhydrase inhibitor when coadministered topically to the eye.