Peter Chris Michels

US Patent:

6613907, Sep 2, 2003

Filed:

Jan 4, 2001

Appl. No.:

09/754786

Inventors:

Peter C. Michels - Des Moines IA
Eric L. Zirbes - Coralville IA

Assignee:

AMR Technology, Inc. - Manchester Center VT

International Classification:

C07D21122

US Classification:

546239, 546240, 546241, 435122, 435135, 435136, 514317

Abstract:

The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R is hydrogen or hydroxy; R is hydrogen; or, when n is 0, R and R taken together form a second bond between the carbon atoms bearing R and R , provided that when n is 1, R and R are each hydrogen; R is âCOOH or âCOOR ; R is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R is âCH and R , R , A, B, and D are defined above In the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Psuedomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Pennicillium. Alternatively, the microorganism can be.

US Patent:

7232908, Jun 19, 2007

Filed:

Aug 11, 2003

Appl. No.:

10/638841

Inventors:

Peter C. Michels - Des Moines IA, US
Eric L. Zirbes - Coralville IA, US

Assignee:

AMR Technology, Inc. - Manchester Center VT

International Classification:

C07D 211/22
C12P 17/12

US Classification:

546239, 546240, 546241, 435122, 435135, 435136, 514317

Abstract:

The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products. Suitable microorganisms can be from any one of the genus of , and. In another aspect of the invention, starting compounds are incubated in the presence of under conditions effective to produce piperidine derivative products.

US Patent:

7538084, May 26, 2009

Filed:

Mar 16, 2004

Appl. No.:

10/802013

Inventors:

Bruce F. Molino - Slingerlands NY, US
Simon N. Haydar - Apex NY, US
Zhicai Yang - Schenectady NY, US
Peter C. Michels - Prospect Heights IL, US
Michael S. Hemenway - Vernon Hills IL, US
Joseph O. Rich - Glenview IL, US
Yuri Khmelnitsky - Addison IL, US

Assignee:

AMR Technology, Inc. - Manchester Center VT

International Classification:

A61K 38/00

US Classification:

514 11

Abstract:

The compounds of the present invention are represented by the chemical structure found in Formula I:.

US Patent:

7691615, Apr 6, 2010

Filed:

Jan 17, 2007

Appl. No.:

11/624096

Inventors:

Peter C. Michels - Des Moines IA, US
Eric L. Zirbes - Coralville IA, US

Assignee:

Albany Molecular Research, Inc. - Albany NY

International Classification:

C12P 17/21

US Classification:

435122, 514317, 546239, 546240, 546241

Abstract:

The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB:This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB:.

US Patent:

20120010163, Jan 12, 2012

Filed:

Sep 17, 2010

Appl. No.:

12/884650

Inventors:

GRANT J. CARR - WOODINVILLE WA, US
DAVID D. MANNING - DUANESBURG NY, US
CHENG GUO - SCHENECTADY NY, US
JUN-HO MAENG - COHOES NY, US
JOHN RABENSTEIN - BURLINGTON WA, US
PETER C. MICHELS - VOORHEESVILLE NY, US
MATTHEW W. CHASE - EAST BERNE NY, US

Assignee:

Albany Molecular Research, Inc. - Albany NY

International Classification:

A61K 31/706
A61K 31/704
A61K 31/7056
C12N 1/20
A61P 31/04
A61P 43/00
C12P 19/28
C07H 5/06
A61K 31/7048

US Classification:

514 43, 536 291, 514 42, 435 85, 4352535

Abstract:

The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.

US Patent:

20220213428, Jul 7, 2022

Filed:

Mar 21, 2022

Appl. No.:

17/699278

Inventors:

- New York NY, US
Malcolm J. KAVARANA - Fairfax VA, US
Mingyang SUN - Vancouver, CA
Peter C. MICHELS - Albany NY, US
John D. RABENSTEIN - Albany NY, US
C. Seth PEARSON - Albany NY, US
Geoffrey M. FOX - Albany NY, US

Assignee:

TEEWINOT LIFE SCIENCES CORPORATION - New York NY

International Classification:

C12M 1/34
C12M 1/36
C12M 1/00
C12M 1/40
C12P 7/42
C12P 17/06

Abstract:

The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.

US Patent:

20190382708, Dec 19, 2019

Filed:

Jun 26, 2019

Appl. No.:

16/453578

Inventors:

- Dublin, IE
Malcolm J. KAVARANA - Fairfax VA, US
Mingyang SUN - Dublin, IE
Peter C. Michels - Voorheesville NY, US
John D. Rabenstein - Feura Bush NY, US
C. Seth Pearson - Albany NY, US
Geoffrey M. Fox - Voorheesville NY, US

International Classification:

C12M 1/34
C12M 1/36
C12M 1/00
C12P 7/42
C12P 17/06

Abstract:

The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.

US Patent:

20180346866, Dec 6, 2018

Filed:

May 10, 2018

Appl. No.:

15/976487

Inventors:

- Dublin, IE
Malcolm J. KAVARANA - Fairfax VA, US
Mingyang SUN - Dublin, IE
Peter C. Michels - Voorheesville NY, US
John D. Rabenstein - Feura Bush NY, US
C. Seth Pearson - Albany NY, US
Geoffrey M. Fox - Voorheesville NY, US

Assignee:

TEEWINOT TECHNOLOGIES LIMITED - Dublin

International Classification:

C12M 1/34
C12P 17/06
C12P 7/42

Abstract:

The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.