Peter F Miller

US Patent:

6403947, Jun 11, 2002

Filed:

Mar 16, 2000

Appl. No.:

09/526938

Inventors:

Clifford C. Hoyt - Needham MA
Richard M. Levenson - Brookline MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research Instrumentation Inc. - Boston MA

International Classification:

G01J 350

US Classification:

250226, 356417

Abstract:

An imaging system is disclosed which provides means for obtaining images with essentially diffraction-limited spatial resolution, and can distinguish between several species of probes within a sample. It may be used with fluorescent, luminescent, up-converting reporter, quantum dot, and other types of probes. Two or more exposures are taken through a filter which expresses different filter states, one of which is preferably a relatively neutral state with high transmission for all wavelengths of interest, and the others of which provide predetermined variation in transmission that are preferably sloping or periodic in wavelength. The probe species is identified by the ratio of response at the various filter settings.

US Patent:

6750964, Jun 15, 2004

Filed:

Jun 25, 2002

Appl. No.:

10/183335

Inventors:

Richard Levenson - Brookline MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G01J 328

US Classification:

356326

Abstract:

A imaging method is described that includes: obtaining a spectral weighting function indicative of an attribute of the reference sample; illuminating a target sample with light whose spectral flux distribution corresponds to the spectral weighting function to produce a corresponding target image, wherein the target image is indicative of a response of the target sample to the corresponding illumination at multiple spatial locations of the target sample; and identifying one or more target features in the target sample based on the target image.

US Patent:

6781736, Aug 24, 2004

Filed:

Nov 2, 2001

Appl. No.:

10/053470

Inventors:

Clifford C. Hoyt - Needham MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F 103

US Classification:

359256, 359246, 359245, 359238, 385 16, 385 18, 385 33

Abstract:

A variable optical attenuator including: a birefringent element positioned to separate an input optical signal into two spatially separated, orthogonally polarized beams; a LC modulator positioned to receive the orthogonally polarized beams and selectively alter their polarizations; a reflective element positioned to reflect the beams back through the LC modulator and the birefringent element, wherein the birefringent element recombines orthogonally polarized components of the reflected beams to produce an output optical signal; and a controller coupled to the LC modulator to selectively cause the LC modulator to alter the polarizations of the orthogonally polarized beams, wherein during operation the controller is responsive to a request to variably attenuate the intensity of the output optical signal relative to the intensity of the input optical signal to one of multiple non-zero attenuation settings.

US Patent:

6927834, Aug 9, 2005

Filed:

May 13, 2002

Appl. No.:

10/144362

Inventors:

Randall J. Deary - Littleton MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F001/13

US Classification:

349158

Abstract:

A method for producing a liquid crystal device, the method including: assembling two substrates to form at least one liquid crystal cell; and removing material from a first one of the assembled substrates to produce a first region of the first substrate that is thinner than a second region of the first substrate.

US Patent:

7046417, May 16, 2006

Filed:

Jul 6, 2004

Appl. No.:

10/885206

Inventors:

Clifford C. Hoyt - Needham MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F 1/03
G02F 1/01
G02B 6/26

US Classification:

359256, 359238, 359245, 359246, 385 16, 385 18, 385 20, 385 24

Abstract:

A variable optical attenuator including: a birefringent element positioned to separate an input optical signal into two spatially separated, orthogonally polarized beams; a LC modulator positioned to receive the orthogonally polarized beams and selectively alter their polarizations; a reflective element positioned to reflect the beams back through the LC modulator and the birefringent element, wherein the birefringent element recombines orthogonally polarized components of the reflected beams to produce an output optical signal; and a controller coupled to the LC modulator to selectively cause the LC modulator to alter the polarizations of the orthogonally polarized beams, wherein during operation the controller is responsive to a request to variably attenuate the intensity of the output optical signal relative to the intensity of the input optical signal to one of multiple non-zero attenuation settings.

US Patent:

7136136, Nov 14, 2006

Filed:

Feb 10, 2005

Appl. No.:

11/055240

Inventors:

Randall J. Deary - Littleton MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F 1/1333

US Classification:

349158, 349160

Abstract:

A method for producing a liquid crystal device, the method including: assembling two substrates to form at least one liquid crystal cell; and removing material from a first one of the assembled substrates to produce a first region of the first substrate that is thinner than a second region of the first substrate.

US Patent:

7782470, Aug 24, 2010

Filed:

Dec 27, 2007

Appl. No.:

12/005471

Inventors:

Peter Domenicali - Wilmington MA, US
Clifford Hoyt - Wellesley MA, US
Scott Determan - North Andover MA, US
Peter Miller - Cambridge MA, US

Assignee:

Cambridge Research Instrumentation, Inc. - Woburn MA

International Classification:

G01B 11/14

US Classification:

356614, 356615

Abstract:

The invention provides for surface mapping of in-vivo imaging subjects using a single camera and a moveable stage on which a subject animal for in-vivo imaging is placed. Images are taken and the stage is moved by known amounts along the optical axis, and the heights of individual features on the subject are determined through analysis of focus, given the known stage displacement. Alternatively, height of sub-regions of the subject are determined through analysis of focus. A mesh or other surface can be constructed from individual features, to provide a surface map of the subject. Accuracy of 0. 5 mm or better can be attained for mice and similarly sized subjects.

US Patent:

7902807, Mar 8, 2011

Filed:

Jul 22, 2008

Appl. No.:

12/220239

Inventors:

Neeraj Arun Keskar - Merrimack NH, US
Peter James Miller - Manchester NH, US

Assignee:

Texas Instruments Incorporated - Dallas TX

International Classification:

G05F 1/40
G05F 1/24

US Classification:

323288, 323259, 323271

Abstract:

A method of and system for modulating buck and boost modulation ramps of a multiple switch node power converter without overlap. As the pulse width or duty cycle of the signal to a modulated complementary switching pair approaches a pre-established reference pulse width or duty cycle, plural fixed-width or fixed duty cycle pulses are generated and introduced to a nonmodulated complementary switching pair. A controller detects proximity to the pulse width or duty cycle limit and, correspondingly, initiates prematurely a pseudo-buck-boost mode in the power converter by generating fixed-width or fixed duty cycle pulses to the nonmodulated complementary switching pair while the duty cycles or pulse widths to the modulated complementary switching pair are still controlled by the appropriate modulation ramp. The net effect is that the power converter reaches its optimal operating point without overlap and eliminates any sub-harmonic switching.