Peter B Miller

US Patent:

6403947, Jun 11, 2002

Filed:

Mar 16, 2000

Appl. No.:

09/526938

Inventors:

Clifford C. Hoyt - Needham MA
Richard M. Levenson - Brookline MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research Instrumentation Inc. - Boston MA

International Classification:

G01J 350

US Classification:

250226, 356417

Abstract:

An imaging system is disclosed which provides means for obtaining images with essentially diffraction-limited spatial resolution, and can distinguish between several species of probes within a sample. It may be used with fluorescent, luminescent, up-converting reporter, quantum dot, and other types of probes. Two or more exposures are taken through a filter which expresses different filter states, one of which is preferably a relatively neutral state with high transmission for all wavelengths of interest, and the others of which provide predetermined variation in transmission that are preferably sloping or periodic in wavelength. The probe species is identified by the ratio of response at the various filter settings.

US Patent:

6750964, Jun 15, 2004

Filed:

Jun 25, 2002

Appl. No.:

10/183335

Inventors:

Richard Levenson - Brookline MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G01J 328

US Classification:

356326

Abstract:

A imaging method is described that includes: obtaining a spectral weighting function indicative of an attribute of the reference sample; illuminating a target sample with light whose spectral flux distribution corresponds to the spectral weighting function to produce a corresponding target image, wherein the target image is indicative of a response of the target sample to the corresponding illumination at multiple spatial locations of the target sample; and identifying one or more target features in the target sample based on the target image.

US Patent:

6781736, Aug 24, 2004

Filed:

Nov 2, 2001

Appl. No.:

10/053470

Inventors:

Clifford C. Hoyt - Needham MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F 103

US Classification:

359256, 359246, 359245, 359238, 385 16, 385 18, 385 33

Abstract:

A variable optical attenuator including: a birefringent element positioned to separate an input optical signal into two spatially separated, orthogonally polarized beams; a LC modulator positioned to receive the orthogonally polarized beams and selectively alter their polarizations; a reflective element positioned to reflect the beams back through the LC modulator and the birefringent element, wherein the birefringent element recombines orthogonally polarized components of the reflected beams to produce an output optical signal; and a controller coupled to the LC modulator to selectively cause the LC modulator to alter the polarizations of the orthogonally polarized beams, wherein during operation the controller is responsive to a request to variably attenuate the intensity of the output optical signal relative to the intensity of the input optical signal to one of multiple non-zero attenuation settings.

US Patent:

6825930, Nov 30, 2004

Filed:

Jun 4, 2002

Appl. No.:

10/163233

Inventors:

Paul J. Cronin - Charlestown MA
Daniel Orband - Lynn MA
Stephen D. Fantone - Lynnfield MA
Peter J. Miller - Newburyport MA

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

F21V 900

US Classification:

356328, 250205, 362231

Abstract:

The invention features a multi-spectral microscopy system for illuminating a sample with light of a selectable spectral content and generating an image of the sample in response to the illumination. The multi-spectral microscopy system includes a multispectral illuminator that provides output radiation having the selectable spectral content. A preferred set of optical arrangements for the multispectral illuminator generates the output radiation so that the spectral content of the output radiation is substantially uniform across its transverse profile. Furthermore, the multispectral illuminator can include monitoring optics and a corresponding detector array that independently monitors the output in each spectral band of the radiation produced by the multispectral illuminator. The monitoring provides calibration, feedback, and/or source aging information to insure robust and reliable performance for the multispectral illuminator. The multi-spectral microscopy system also includes a microscope which illuminates the sample with light derived from the output of the multispectral illuminator, and beam modification optics, which modify the output from the lamp prior to the microscope to increase the light efficiency of the microscope and fully exploit field of view and resolution of the microscope.

US Patent:

6927834, Aug 9, 2005

Filed:

May 13, 2002

Appl. No.:

10/144362

Inventors:

Randall J. Deary - Littleton MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F001/13

US Classification:

349158

Abstract:

A method for producing a liquid crystal device, the method including: assembling two substrates to form at least one liquid crystal cell; and removing material from a first one of the assembled substrates to produce a first region of the first substrate that is thinner than a second region of the first substrate.

US Patent:

6930773, Aug 16, 2005

Filed:

Aug 23, 2002

Appl. No.:

10/226592

Inventors:

Paul J. Cronin - Charlestown MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G01J003/00

US Classification:

356300, 356320, 25033912

Abstract:

A method is described that includes measuring, at each of a set of W wavelength bins, a spectral response of at least one region of a sample stained with multiple stains, and determining the concentration of at least one of the stains in the region of the sample based in part on the spectral responses, the wavelength bins being chosen so that a matrix of elements that represent the responses of the stains at the wavelength bin has an inverse for which a mathematical stability is maximum relative to the inverses of other matrices of elements that represent the responses of the stains for other possible sets of wavelength bins.

US Patent:

7046417, May 16, 2006

Filed:

Jul 6, 2004

Appl. No.:

10/885206

Inventors:

Clifford C. Hoyt - Needham MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Cambridge Research and Instrumentation, Inc. - Woburn MA

International Classification:

G02F 1/03
G02F 1/01
G02B 6/26

US Classification:

359256, 359238, 359245, 359246, 385 16, 385 18, 385 20, 385 24

Abstract:

A variable optical attenuator including: a birefringent element positioned to separate an input optical signal into two spatially separated, orthogonally polarized beams; a LC modulator positioned to receive the orthogonally polarized beams and selectively alter their polarizations; a reflective element positioned to reflect the beams back through the LC modulator and the birefringent element, wherein the birefringent element recombines orthogonally polarized components of the reflected beams to produce an output optical signal; and a controller coupled to the LC modulator to selectively cause the LC modulator to alter the polarizations of the orthogonally polarized beams, wherein during operation the controller is responsive to a request to variably attenuate the intensity of the output optical signal relative to the intensity of the input optical signal to one of multiple non-zero attenuation settings.

US Patent:

7079247, Jul 18, 2006

Filed:

Jul 8, 2003

Appl. No.:

10/616328

Inventors:

Mykhailo Shribak - Woods Hole MA, US
Rudolf Oldenbourg - Falmouth MA, US
Paul J. Cronin - Charlestown MA, US
Clifford C. Hoyt - Somerville MA, US
Peter J. Miller - Newburyport MA, US

Assignee:

Marine Biological Laboratory - Woods Hole MA

International Classification:

G01J 4/00

US Classification:

356364

Abstract:

The invention provides a highly sensitive measurement of retardance and slow axis orientation, accurately and instantaneously, across a full two-dimensional image. There are no moving parts and there need not be any electro-optic tuning as part of the measurement. It is ideally adapted to real-time imaging and is well-suited to use with biological and medical samples, including visualizing structures in oocytes. The invention splits a light beam into several beams, which are analyzed using elliptical polarizers and the resultant intensity is measured. It can be constructed using a single pixilated detector, or several detectors, to achieve high spatial resolution when this is desired.

Address:

965 Cottage Grv Ave, Las Vegas, NV 89119

VIN:

5NPET46C77H272158

Make:

HYUNDAI

Model:

SONATA

Year:

2007