Herman A. de Boer - Pacifica CA Peter H. Seeburg - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 710
US Classification:
530350
Abstract:
Novel amino terminal methionyl embodiments of bovine growth hormone are prepared in recombinant cell culture. Amino terminal methionyl derivatives of bovine growth hormone are particularly useful in enhancing milk production by dairy cattle.
Method For Cloning Human Growth Hormone Varient Genes
A novel non-allelic human growth hormone variant is disclosed. It is prepared by a new method of obtaining cDNA from the genomic sequences of a eukaryotic organism.
Methods And Products For Facile Microbial Expression Of Dna Sequences
Herman A. de Boer - Pacifica CA Peter H. Seeburg - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12P 2102 C12N 1571 C12N 1570 C12N 1503
US Classification:
435 694
Abstract:
Expression levels of polypeptides in recombinant host cell culture are increased by the use of synthetic DNA sequences chosen so that the mRNA transcribed therefrom is free of secondary structure sufficient to interfere with the efficiency of mRNA translation.
Novel Human Growth Hormone Like Protein Hgh-V Encoded In The Human Genome
A novel non-allelic human growth hormone variant protein is disclosed. The structure of the protein is determined and the protein product is produced by recombinant DNA methods.
Peter H. Seeburg - San Francisco CA John P. Adelman - Eugene OR
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12P 2102 C12N 510 C12N 1516
US Classification:
435 694
Abstract:
DNA encoding a novel polypeptide hormone, designated CTP, has been identified in the human genome. CTP is expressed as a fusion protein (proLHRH) with luteinizing hormone releasing hormone (LHRH), and is post-translationally processed to CTP and LHRH. CTP, its derivatives, and its fusions, including proLHRH, are useful in therapy and diagnostics.
Nucleic Acid Encoding The Mature .Beta..sub.b Chain Of Inhibin And Method For Synthesizing Polypeptides Using Such Nucleic Acid
Anthony J. Mason - San Francisco CA Peter H. Seeburg - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 1516 C12N 1563
US Classification:
435 694
Abstract:
DNA encoding the prepro inhibin. alpha. and. beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin. alpha. or. beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
Nucleic Acid Encoding The .Alpha. Chain Prodomains Of Inhibin And Method For Synthesizing Polypeptides Using Such Nucleic Acid
Anthony J. Mason - San Francisco CA Peter H. Seeburg - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12P 2102 C12N 1512 C12N 121 C12N 510
US Classification:
435 691
Abstract:
DNA encoding the prepro inhibin. alpha. and. beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin. alpha. or. beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
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