Peter K Williams

US Patent:

6356262, Mar 12, 2002

Filed:

Apr 15, 1999

Appl. No.:

09/292704

Inventors:

James Thomas Klosowski - Rye NY
Claudio T. Silva - Mahwah NJ
Gabriel Taubin - Hartsdale NY
Peter Lawrence Williams - Livermore CA
Joseph Shannon Baird Mitchell - Port Jefferson NY
Joao Luiz Dihl Comba - Stanford CA

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06T 1540

US Classification:

345421, 345619

Abstract:

The visibility ordering of polyhedral cells is efficiently determined by building an ordering graph, comprising oriented edges between two cells. Each edge (A,B) corresponds to the fact that cell A has to be projected, or rendered, before B. A set of ordering relations and rules that can be shown to generate, if one exists, a global ordering of the polyhedral cell complex. Three different types of edges are used to accomplish this: MPVO, BSP and PPC edges. MPVO edges exist between two cells that share a face. To define the BSP edges, a BSP-tree of the boundary faces of the cell complex is constructed. During this construction, some of the boundary faces of the cells will be âcutâ by the BSP-tree âextendedâ faces, into multiple pieces. If C is the boundary cell, and câ, câ, and so on, are the pieces of its boundary faces, the BSP_edge (câ, C) is defined to mean that cell C can only be projected after câ has been projected by the BSP. A cell C is in the PPC if one of the pieces that compose it, say câ, has been projected by the BSP, but there exist other pieces of cell C that have not been projected.

US Patent:

6455532, Sep 24, 2002

Filed:

Jun 1, 2000

Appl. No.:

09/585112

Inventors:

Christopher S. Burgey - Plymouth Meeting PA
Kyle A. Robinson - Elkins Park PA
Peter D. Williams - Harleysville PA
Craig Coburn - Royersford PA
Terry A. Lyle - Lederach PA
Philip E. Sanderson - Philadelphia PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31497

US Classification:

51425502, 544405

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: A is âwherein Y and Y are independently hydrogen, C alkyl, C alkoxy, F H C(CH ) Oâ, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1, C cycloalkyl, thio C alkyl, C sulfinylalkyl, C sulfonylalkyl, halogen cyano, or trifluoromethyl, and wherein b is 0 or 1.

US Patent:

6515011, Feb 4, 2003

Filed:

Dec 18, 2001

Appl. No.:

10/023776

Inventors:

Harold G. Selnick - Ambler PA
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Peter D. Williams - Harleysville PA
Kenneth J. Stauffer - Souderton PA
Philip E. Sanderson - Philadelphia PA
Kenneth E. Rittle - Green Lane PA
Matthew M. Morrissette - Pottstown PA
Catherine M. Wiscount - Allentown PA
Lekhanh O. Tran - Norristown PA
Terry A. Lyle - Lederach PA
Donnette D. Staas - Harleysville PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3140

US Classification:

514423, 548538, 548528, 548518, 546111, 5462791, 514422, 514343, 514290

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. where R is âCH NH , âCH CH NH , or âCH NHC(O)OC(CH ).

US Patent:

6528503, Mar 4, 2003

Filed:

Jun 14, 2002

Appl. No.:

10/171708

Inventors:

Peter D. Williams - Harleysville PA
Terry A. Lyle - Lederach PA
Matthew M. Morrissette - Pottstown PA
Lekhanh O. Tran - Norristown PA
Donnette D. Staas - Harleysville PA

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 31397

US Classification:

514210, 548953, 5462681, 514340

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.

US Patent:

7026324, Apr 11, 2006

Filed:

Feb 5, 2002

Appl. No.:

10/470936

Inventors:

Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
Harold G. Selnick - Ambler PA, US
Peter D. Williams - Harleysville PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4965
C07D 401/00
C07D 403/00
C07D 405/00
C07D 409/00

US Classification:

51425505, 544405, 5462684, 514338, 514339

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein R2 is R3 is selected from the group consisting of 1) hydrogen, 2) halogen, 3) C1–4 alkyl, 4) C3–7 cycloalkyl, 5) CF3, 6) OCF3, 7) C1–4 alkoxy, and 8) cyano; and R12 is a 5-membered heteroaryl ring having 2, 3, or 4 heteroatoms, provided that at least 1 heteroatom is N, and at most 1 of the heteroatoms is S, said ring being unsubstituted or substituted, at any one ring atom, with CH3.

US Patent:

7144899, Dec 5, 2006

Filed:

Feb 5, 2002

Appl. No.:

10/467439

Inventors:

Harold G. Selnick - Ambler PA, US
Mary Beth Young - Lansdale PA, US
Philippe G. Nantermet - Lansdale PA, US
James C. Barrow - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Donnette D. Staas - Harleysville PA, US
Kenneth J. Stauffer - Souderton PA, US
Philip E. Sanderson - Philadelphia PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/4439
C07D 401/12

US Classification:

514340, 514361, 5462687, 5462691, 548127, 548131, 548134

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R)CH(R)— wherein the nitrogen atom is attached to R, and Rand Rare independently selected from the group consisting of hydrogen, Ccycloalkyl, and Calkyl, or 2) wherein the nitrogen atom is attached to R, and m is 0, 1, or 2.

US Patent:

7476666, Jan 13, 2009

Filed:

Jun 3, 2005

Appl. No.:

11/629153

Inventors:

John S. Wai - Harleysville PA, US
Peter D. Williams - Harleysville PA, US
H. Marie Langford - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 487/04
C07D 413/06
C07D 471/04
A61K 31/55
A61K 31/535
A61K 31/495
A61P 31/18

US Classification:

514221, 5142332, 514250, 540502, 544117, 544346, 544350

Abstract:

Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:.

US Patent:

7517532, Apr 14, 2009

Filed:

Sep 10, 2003

Appl. No.:

10/526275

Inventors:

John S. Wai - Harleysville PA, US
Boyoung Kim - Lansdale PA, US
Thorsten E. Fisher - Hatfield PA, US
Peter D. Williams - Harleysville PA, US
H. Marie Langford - Lansdale PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 39/21
C07D 241/00
C07D 241/02
C07D 241/36
C07D 471/00
C07D 487/00
C07D 491/00
C07D 495/00
C07D 497/00

US Classification:

4242081, 544336, 544349, 544350

Abstract:

8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.