Philippe H Marambaud

US Patent:

8420309, Apr 16, 2013

Filed:

Aug 8, 2008

Appl. No.:

12/733096

Inventors:

Philippe Marambaud - Astoria NY, US
Fabien Campagne - Astoria NY, US

Assignee:

The Feinstein for Medical Research - Manhasset NY
Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61P 25/28
C40B 30/00
C40B 30/06
C12Q 3/00
C12Q 1/68
A61K 38/00
C07K 1/00

US Classification:

435 4, 435 61, 506 7, 514 11, 530350

Abstract:

Provided are methods of screening test compounds for the ability to alter calcium homeostasis in mammalian cells by experimentally determining if a compound affects CALHM1, CALHM2, or CALHM3 expression or activity. Additionally provided are methods of screening a test compound for the ability to inhibit ERK 1/2 phosphorylation in a mammalian cell. Further provided are methods of screening a test compound for the ability to inhibit amyloid-beta peptide accumulation in a mammalian cell or biological fluid, methods of screening for a test compound that may affect Alzheimer's disease and methods of determining the likelihood that a subject will be diagnosed with Alzheimer's disease. Also provided are isolated and purified mammalian CALHM proteins, vectors comprising a nucleic acid sequence encoding the CALHM1, CALHM2, and CALHM3 proteins, and mammalian cells transfected with the vectors. Additionally, methods of affecting Ca2+ levels in a mammalian cell are provided.

US Patent:

20050245453, Nov 3, 2005

Filed:

Apr 10, 2003

Appl. No.:

10/509170

Inventors:

Nickolaos Robakis - Leonia NJ, US
Philippe Marambaud - New York NY, US
Anastasios Georgakopoulos - New York NY, US

International Classification:

C12Q001/37
A61K038/10
A61K038/08
C07K007/08
C07K007/06

US Classification:

514014000, 514015000, 514016000, 514017000, 530326000, 530327000, 530328000, 530329000, 530330000, 435023000

Abstract:

The present invention provides polypeptides and peptides derived from cadherin. The polypeptides and peptides are useful in a method of inhibiting amyloid deposition and a method of inhibiting tumor metastasis. A method of determining susceptibility to Alzheimer's disease and a method of screening for agents that modify cadherin processing are also provided.

US Patent:

20230075244, Mar 9, 2023

Filed:

Feb 17, 2021

Appl. No.:

17/799397

Inventors:

- Manhasset NY, US
Philippe Marambaud - Astoria NY, US

International Classification:

C07K 16/28
A61P 35/00

Abstract:

Provided are agonist anti-ENG coreceptor-specific antibodies and agonist anti-ENG coreceptor-binding fragments thereof, including antibodies that bind to the BMP9-binding region within an ectodomain of an ENG coreceptor, as well as methods of use employing such antibodies and/or fragments in treating diseases such as HHT and PAH.

US Patent:

20210346355, Nov 11, 2021

Filed:

Sep 24, 2019

Appl. No.:

17/274725

Inventors:

- Manhasset NY, US
Philippe MARAMBAUD - Astoria NY, US

Assignee:

THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH - Manhasset NY

International Classification:

A61K 31/436
A61K 31/496
A61P 7/04
A61P 7/06

Abstract:

Methods and pharmaceutical compositions comprising one or more mTOR inhibitors such as sirolimus and one or more receptor tyrosine kinase inhibitors such as nintedanib are disclosed for treating vascular lesions and hereditary hemorrhagic telangiectasia.