Phillip I Tarr

US Patent:

6727073, Apr 27, 2004

Filed:

Nov 19, 1999

Appl. No.:

09/443211

Inventors:

Norman Moore - North Berwick ME
Phillip I. Tarr - Seattle WA

Assignee:

Binax, Inc. - Portland ME

International Classification:

G01N 3353

US Classification:

435 732, 435 737, 435 794, 435 287, 4352878, 435 30, 436518, 436526, 436536, 436538, 436161, 436810

Abstract:

A method for determining and diagnosing inflammatory enteric disease using an immunochromatographic test device having a multiplicity of test zones. The method tests for the presence of at least one enteric pathogen and at least one of certain inflammatory enteric disease markers. The enteric pathogens tested for can be any number of enteric pathogens such as the pathogens O157, Campylobacter, Salmonella, Listeria, Shigella, and Yersinia. The inflammatory enteric disease markers tested for are fecal lactoferrin, a bacteria marker, a virus marker, and a protozoa marker. Positive results for any one of the pathogens indicates that pathogen as the cause of the inflammatory enteric disease. Positive results for fecal lactoferrin indicate an inflammatory condition of the intestines. Positive results for the bacteria, virus, protozoa markers indicate respectively a bacterial, viral, or protozoan cause of infection as the cause of the disease. Liquid fecal sample is mixed with a mixture containing antibodies to the pathogens and the markers.

US Patent:

8597877, Dec 3, 2013

Filed:

Apr 12, 2007

Appl. No.:

11/787195

Inventors:

Phillip I. Tarr - Seattle WA, US

Assignee:

Seattle Children's Hospital - Seattle WA

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/02
C07H 21/04

US Classification:

435 61, 435 911, 435 912, 536 231, 536 243

Abstract:

The present invention relates generally to the field of microbiology and food sciences. More particularly, the inventor has discovered several polynucleotide sequences encoding the gnd gene and corresponding 6-phosphogluconate dehydrogenase (6-PGD) proteins from different strains of and polymorphic sequences therein. Novel biotechnological tools, diagnostics, and food screening techniques are provided.

US Patent:

20020150902, Oct 17, 2002

Filed:

Jun 5, 2001

Appl. No.:

09/875573

Inventors:

Phillip Tarr - Seattle WA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/00
C12N001/21
C12P021/02
C12N015/70

US Classification:

435/006000, 435/069300, 435/183000, 435/252330, 435/320100, 536/023700

Abstract:

The present invention relates generally to the field of microbiology and food sciences. More particularly, the inventor has discovered several polynucleotide sequences encoding the gnd gene and corresponding 6-phosphogluconate dehydrogenase (6-PGD) proteins from different strains of and polymorphic sequences therein. Novel biotechnological tools, diagnostics, and food screening techniques are provided.

US Patent:

20050074459, Apr 7, 2005

Filed:

Jul 23, 2003

Appl. No.:

10/625972

Inventors:

Phillip Tarr - Seattle WA, US
Sima Bilge - Bellevue WA, US
Thomas Besser - Moscow ID, US
James Vary - Seattle WA, US

International Classification:

A61K039/00
A61K039/38

US Classification:

424184100

Abstract:

Polypeptides encoded by a continuous segment of chromosomal DNA from O157:H7, isolated on plasmid pSC(overlap)(ATCC No. 69648), that encodes an adhesin (SEQ ID NO:5) that mediates bacterial colonization of bovine intestines, vaccines derived therefrom, and antibodies directed against the adhesin are disclosed.

US Patent:

60404213, Mar 21, 2000

Filed:

Jun 16, 1998

Appl. No.:

9/098082

Inventors:

Phillip I. Tarr - Seattle WA
Sima S. Bilge - Bellevue WA
Thomas E. Besser - Moscow ID
James C. Vary - Seattle WA

Assignee:

Children's Hospital and Medical Center - Seattle WA
University of Washington - Seattle WA
University Research Foundation - Pullman WA

International Classification:

A61K 3800
A61K 3902
A61K 39108
A61K 3900
C07C24500

US Classification:

530300

Abstract:

Polypeptides encoded by a continuous segment of chromosomal DNA from E. coli O157:H7, isolated on plasmid pSC(overlap) (ATCC No. 69648), that encodes an adhesin (SEQ ID NO:5) that mediates bacterial colonization of bovine intestines, vaccines derived therefrom, and antibodies directed against the adhesin.

US Patent:

57982600, Aug 25, 1998

Filed:

Mar 26, 1997

Appl. No.:

8/765081

Inventors:

Phillip I. Tarr - Seattle WA
Sima S. Bilge - Bellevue WA
Thomas E. Besser - Moscow ID
James C. Vary - Seattle WA

Assignee:

Children's Hospital and Medical Center - Seattle WA
University of Washington - Seattle WA
Washington State University Research Foundation - Pullman WA

International Classification:

C12N 121
C12N 1563
C07H 2104

US Classification:

4352523

Abstract:

A continuous segment of chromosomal DNA from E. coli O157:H7, isolated on plasmid pSC(overlap) (ATCC No. 69648), encodes an adhesin (SEQ ID NO:4) that mediates bacterial colonization of bovine intestines.

US Patent:

56544170, Aug 5, 1997

Filed:

Apr 14, 1995

Appl. No.:

8/423564

Inventors:

Phillip I. Tarr - Seattle WA
Sima S. Bilge - Bellevue WA
James C. Vary - Seattle WA

Assignee:

Children's Hospital and Medical Center - Seattle WA
University of Washington - Seattle WA

International Classification:

C07H 2104
C12Q 168

US Classification:

536 2432

Abstract:

An isolated nucleic acid molecule that hybridizes under stringent conditions to SEQ ID NO:1 or its complement and to the DNA of enterohemorrhagic E. coli O157:H7 but not to the DNA of enteropathogenic E. coli O55:H7.

US Patent:

20220241438, Aug 4, 2022

Filed:

Feb 22, 2022

Appl. No.:

17/652037

Inventors:

- St. Louis MO, US
Steven J. Hanley - Wildwood MO, US
Phillip I. Tarr - Clayton MO, US

International Classification:

A61K 49/00

Abstract:

Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.