Philomen Z Decroos

US Patent:

20140094610, Apr 3, 2014

Filed:

Oct 3, 2013

Appl. No.:

14/045033

Inventors:

- Foster City CA, US
Philomen DECROOS - Middlebury CT, US
Keith R. FANDRICK - Sandy Hook CT, US
Joe Ju GAO - Southbury CT, US
Nizar HADDAD - Danbury CT, US
Zhi-Hui LU - Newtown CT, US
Bo QU - Brookfield CT, US
Sonia RODRIGUEZ - New Milford CT, US
Chris H. SENANAYAKE - Brookfield CT, US
Yongda ZHANG - Sandy Hook CT, US
Wenjun TANG - Southbury CT, US

International Classification:

C07D 491/06
C07D 417/02
C07D 409/02
C07D 401/02
C07D 215/14
C07D 405/02

US Classification:

546 89, 546173, 546 99

Abstract:

The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.