Ping Liu Li

US Patent:

8435563, May 7, 2013

Filed:

Jan 3, 2012

Appl. No.:

13/342533

Inventors:

Yu Cao - Parsippany NJ, US
Yatindra Joshi - Princeton NJ, US
Ping Li - Basking Ridge NJ, US
Madhusudhan Pudipeddi - Mumbai, IN
Alan E Royce - Saylorsburg PA, US
Robert F Wagner - Hillsborough NJ, US
Jiahao Zhu - Whippany NJ, US

Assignee:

Novartis Pharmaceuticals Corporation - East Hanover NJ

International Classification:

A61K 31/549
A61K 9/28
A61P 9/12
A61P 9/04
A61P 9/10
A61P 9/00

US Classification:

424464, 427 214, 5142232, 5142235, 514355, 514381

Abstract:

Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.

US Patent:

8475839, Jul 2, 2013

Filed:

Jan 3, 2012

Appl. No.:

13/342533

Inventors:

Yu Cao - Parsippany NJ, US
Yatindra Joshi - Princeton NJ, US
Ping Li - Basking Ridge NJ, US
Madhusudhan Pudipeddi - Mumbai, IN
Alan E Royce - Saylorsburg PA, US
Robert F Wagner - Hillsborough NJ, US
Jiahao Zhu - Whippany NJ, US

Assignee:

Novartis AG - Basel

International Classification:

A61K 31/549
A61K 9/28
A61P 9/12
A61P 9/04
A61P 9/10
A61P 9/00

US Classification:

424464, 427 214, 5142232, 5142235, 514355, 514381

Abstract:

Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.

US Patent:

20080064760, Mar 13, 2008

Filed:

Oct 27, 2005

Appl. No.:

11/575203

Inventors:

Ping Li - Basking Ridge NJ, US
Madhusudhan Pudipeddi - Edison NJ, US
Alan Royce - Saylorsburg PA, US
Sara Hynes - New Haven CT, US
Abu Serajuddin - Queens NY, US
Michael Ambuhl - Rheinfelden, CH
Barbara Luckel - Lorrach, DE

International Classification:

A61K 47/00

US Classification:

514772100

Abstract:

A spontaneously dispersible pharmaceutical composition comprising a poorly soluble drug and a carrier medium comprising (1) a lipophilic component, (2) a surfactant, and optionally (3) a hydrophilic component, wherein at least one of the components (1) to (3) is solid at room temperature. A particularly useful hydrophilic component in the system is a polymer that is solid at room temperature, e.g., solid PEG.

US Patent:

20080096972, Apr 24, 2008

Filed:

Jul 29, 2005

Appl. No.:

11/572028

Inventors:

Thitiwan Buranachokpaisan - Morristown NJ, US
Rose-Marie Dannenfelser - Bloomfield NJ, US
Ping Li - Basking Ridge NJ, US

International Classification:

A61K 31/135
A61P 37/00

US Classification:

514653

Abstract:

Pharmaceutical concentrate formulations comprising 2-amino-1,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.

US Patent:

20090218714, Sep 3, 2009

Filed:

Feb 25, 2009

Appl. No.:

12/392344

Inventors:

Ping Li - Basking Ridge NJ, US
Mark Robert Mecadon - Basking Ridge NJ, US
Jiahao Zhu - Whippany NJ, US

International Classification:

B29C 43/02
B28B 3/00

US Classification:

264101, 425363, 4254051

Abstract:

The invention relates to apparatus for filling a cavity during production of a pharmaceutical dosage form. The apparatus comprises a cavity open at an upper surface and closed at a lower surface. The lower surface is defined by an initial layer of powder. A powder source and a fluid pump are also provided. The fluid pump is arranged to draw gas away from the cavity such that the gas pressure within the cavity is reduced below the ambient gas pressure before the cavity is filled to a predetermined fill level with powder from the powder source.

US Patent:

20100003321, Jan 7, 2010

Filed:

Jun 26, 2007

Appl. No.:

11/915096

Inventors:

Yu Cao - Parsippany NJ, US
Yatindra Joshi - Princeton NJ, US
Ping Li - Basking Ridge NJ, US
Madhusudhan Pudipeddi - Mumbai, IN
Alan E. Royce - Saylorsburg PA, US
Robert F. Wagner - Hillsborough NJ, US
Jiahao Zhu - Whippany NJ, US

International Classification:

A61K 31/549
A61K 9/20
A61P 9/00
A61P 25/00

US Classification:

424474, 5142235, 424464

Abstract:

Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.

US Patent:

20130245061, Sep 19, 2013

Filed:

Dec 1, 2011

Appl. No.:

13/989250

Inventors:

Yu Cao - Montville NJ, US
Wolfgang Hackl - Loerach, DE
Ping Li - Basking Ridge NJ, US
Shoufeng Li - Basking Ridge NJ, US
Tahseen Mirza - Rockville MD, US
Hartmut Zehender - Fulleren, FR
Jiahao Zhu - Whippany NJ, US

Assignee:

NOVARTIS AG - Basel

International Classification:

C07D 471/04

US Classification:

514293, 264118

Abstract:

A pharmaceutical composition for the oral administration of a therapeutic compound of formula (I), comprising granules that comprise at least therapeutic compound of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof; at least one non-ionic surfactant that is Vitamin E-TPGS in an amount ranging from about 15 to about 80% by weight of the composition; and at least one a dissolution enhancing agent selected from polyethylene glycol, polyethylene oxide, and any combination of the foregoing; processes for making such pharmaceutical compositions; a kit comprising such pharmaceutical composition and the instructions for administration thereof; and related uses and methods of treatment.

US Patent:

20190054086, Feb 21, 2019

Filed:

Mar 14, 2018

Appl. No.:

15/921306

Inventors:

- Boulder CO, US
Yogita Krishnamachari - Springfield NJ, US
Xiaohong Shen - Livingston NJ, US
Hanchen Lee - Teaneck NJ, US
Ping Li - Basking Ridge NJ, US
Rajinder Singh - Sewaren NJ, US
LayChoo Tan - Bridgewater NJ, US

International Classification:

A61K 31/506
A61K 9/20
A61K 9/00
A61K 9/28
A61K 9/48

Abstract:

This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2- yl)carbamate (COMPOUND A) and the use of these formulations for treating proliferative diseases, such as solid tumor diseases.