Radikal Therapeutics - 100 Cummings Centre, Beverly, MA 01915 since 2011
Senior Director, Chemistry
Greater Boston Area Apr 2010 - 2011
Medicinal Chemistry & Drug Discovery Research Professional
Inotek Pharmaceuticals Jul 1999 - Mar 2010
Director, Medicinal Chemistry
Laboratory for Drug Discovery in Neurodegeneration-Harvard University - Cambridge, MA Sep 2001 - Dec 2002
Scientist
Virginia Tech - Department of Chemistry, Blacksburg, VA Jun 1996 - Jun 1999
Post Doc
Education:
Virginia Polytechnic Institute and State University 1996 - 1999
University of Pune 1989 - 1992
Ph.D., Chemistry
Skills:
Drug Discovery Medicinal Chemistry Chemistry Pharmacology Biotechnology Organic Synthesis Organic Chemistry Biopharmaceuticals Clinical Trials Drug Development Lead Change Cancer Chromatography Patents Catalysis
Name / Title
Company / Classification
Phones & Addresses
Prakash Jagtap Assistant
Radikal Therapeutics Incorporated Medical Laboratory
100 Cummings Ctr, Beverly Farms, MA 01915 (978)9693195
This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, prodrug, or mixture thereof are also described.
Methods For The Treatment Of Neurodegenerative Disorders Using Substituted Phenanthridinone Derivatives
This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. The invention also includes pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable salt, hydrate, prodrug, or mixture thereof. Methods of using the compounds and pharmaceutical compositions for treating neurodegenerative disorders, such as multiple sclerosis are also described.
7-Substituted Isoindolinone Inhibitors Of Inflammation And Reperfusion Injury And Methods Of Use Thereof
The invention provides a novel class of substituted isoindolinone derivatives, useful for the treatment of inflammation and reperfusion injuries. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, stereoisomers or mixtures thereof are also described. The novel isoindolinone derivatives have the formula: or a pharmaceutically acceptable base or acid addition salt, hydrate, stereoisomer, or mixtures thereof, wherein R is described herein.
Substituted Indeno[1,2-C]Isoquinoline Derivatives And Methods Of Use Thereof
The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described.
Prakash Jagtap - Beverly MA, US Garry Southan - Salem MA, US Andrew Salzman - Belmont MA, US Csaba Szabo - Gloucester MA, US Siya Ram - Winchester MA, US
The invention provides a novel class of substituted nucleoside derivatives having the formula:A-Z1-L-Z2-Gwherein:Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, or mixtures thereof are also described.
Isoquinoline Derivatives And Methods Of Use Thereof
Prakash Jagtap - Beverly MA, US Erkan Baloglu - Boston MA, US John H. van Duzer - Georgetown MA, US Csaba Szabo - Gloucester MA, US Andrew L. Salzman - Belmont MA, US
Assignee:
Inotek Pharmaceuticals Corporation - Beverly MA
International Classification:
A61K031/5377 A61K031/473 C07D413/12 C07D221/18
US Classification:
5142328, 544125, 544361, 546 61, 514253, 514284
Abstract:
The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
Tetracyclic Benzamide Derivatives And Methods Of Use Thereof
Prakash Jagtap - Beverly MA, US Csaba Szabo - Gloucester MA, US
Assignee:
Inotek Pharmaceuticals Corporation - Beverly MA
International Classification:
A61K 31/5377 A61K 31/473 C07D 413/12 C07D 221/18
US Classification:
5142328, 544125, 546 61, 514284
Abstract:
The invention relates to Tetracyclic Benzamide Derivatives; compositions comprising a Tetracyclic Benzamide Derivative; and methods for treating or preventing an inflammatory disease, a reperfusion disease, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Benzamide Derivative.
Tetracyclic Amino And Carboxamido Compounds And Methods Of Use Thereof
Prakash Jagtap - North Andover MA, US Csaba Szabo - Budapest, HU
Assignee:
Inotek Pharmaceuticals Corporation - Beverly MA
International Classification:
A61K 31/5377 C07D 413/12
US Classification:
5142328, 544125, 546 61, 514284
Abstract:
The present invention relates to Tetracyclic Amino Compounds and Tetracyclic Carboxamido Compounds, compositions comprising an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, Parkinson's disease, renal failure, a vascular disease, a cardiovascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Amino Compound or a Tetracyclic Carboxamido Compound.
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