Qiaolin Chen

US Patent:

20100310465, Dec 9, 2010

Filed:

Jul 22, 2010

Appl. No.:

12/841331

Inventors:

Jeffrey I. Zink - Sherman Oaks CA, US
Jie Lu - Los Angeles CA, US
Fuyuhiko Tamanoi - Los Angeles CA, US
Andre Nel - Sherman Oaks CA, US
Sarah Angelos - Corvallis OR, US
Fraser Stoddart - Evanston IL, US
Qiaolin Chen - Los Angeles CA, US
Tian Xia - Los Angeles CA, US
Kaushik Patel - Bayside WI, US
William Dichtel - Ithaca NY, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 9/14
A61K 31/352
A61P 27/02
A61P 39/06
A61P 29/00
A61P 37/06
A61P 35/00
A61P 25/08
A61P 31/12
A61P 9/12
A61P 7/02
B01J 19/00
A61K 49/00

US Classification:

424 91, 514454, 424489, 422105, 977724

Abstract:

A nanodevice has a containment vessel defining a storage chamber therein and defining at least one port to provide access to and from said storage chamber, and a stopper assembly attached to the containment vessel. The stopper assembly has a blocking unit arranged proximate the at least one port and has a structure suitable to substantially prevent material after being loaded into the storage chamber from being released while the blocking unit is arranged in a blocking configuration. The stopper assembly is responsive to the presence of a predetermined stimulus such that the blocking unit is released in the presence of the predetermined stimulus to allow the material to be released from the storage chamber. The predetermined stimulus is a predetermined catalytic activity that is suitable to at least one of cleave, hydrolyze, oxidize, or reduce a portion of the stopper assembly, and the nanodevice has a maximum dimension of about 1 μm.