Qing Yang

US Patent:

20200347409, Nov 5, 2020

Filed:

Jan 29, 2019

Appl. No.:

16/962509

Inventors:

- Oakland CA, US
Xiaobin Xu - Los Angeles CA, US
Natcha Wattanatorn - Los Angeles CA, US
Qing Yang - Los Angeles CA, US
Steven J. Jonas - Hawthorne CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12N 15/87
G01N 33/543

Abstract:

A method of transporting biomolecular cargo intracellularly into cells includes the operations of providing magnetic nanostructures (e.g., nanospears, nanostars, nanorods, and other nanometer-sized structures) carrying the biomolecular cargo thereon and applying an external magnetic field to move the magnetic nanostructures into physical contact with at least some of the cells (or the cells into the magnetic nanostructures). The magnetic nanostructures move into physical contact with a single cell, a subset of cells, or all cells. The external magnetic field may be applied by a moving permanent magnet although an electromagnetic may also be used. The biomolecular cargo may include a molecule, a plurality of molecules, or higher order biological constructs. For example, the biological construct may include DNA plasmids, small interfering RNA, proteins, or targeted nuclease gene-editing cargo such as zinc-finger nucleases, transcription activator-like effector nucleases, Cas9 protein, Cas9 mRNA, and associated guide RNA sequences.

US Patent:

20200098577, Mar 26, 2020

Filed:

Sep 25, 2019

Appl. No.:

16/583101

Inventors:

- Oakland CA, US
Qing Yang - Los Angeles CA, US
Natcha Wattanatorn - Los Angeles CA, US
Chuanzhen Zhao - Los Angeles CA, US
Logan A. Stewart - Los Angeles CA, US
Steven J. Jonas - Hawthorne CA, US
Paul S. Weiss - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01L 21/308
H01L 21/3065

Abstract:

A robust and general fabrication/manufacturing method is described herein for the fabrication of periodic three-dimensional (3D) hierarchical nanostructures in a highly scalable and tunable manner. This nanofabrication technique exploits the selected and repeated etching of spherical particles that serve as resist material and that can be shaped in parallel for each processing step. The method enables the fabrication of periodic, vertically aligned nanotubes at the wafer scale with nanometer-scale control in three dimensions including outer/inner diameters, heights/hole-depths, and pitches. The method was utilized to construct 3D periodic hierarchical hybrid silicon and hybrid nanostructures such as multi-level solid/hollow nanotowers where the height and diameter of each level of each structure can be configured precisely as well as 3D concentric plasmonic supported metal nanodisk/nanorings with tunable optical properties on a variety of substrates.