84 Colley Brook Dr, Windham, ME 04062 • (207)8928690
South Portland, ME
Salt Lake City, UT
S Portland, ME
2344 E Rockview Dr, Sandy, UT 84092
Work
Company:
University of utah
Jun 2011
Position:
Research associate
Education
School / High School:
University of Turin- Torino, Piemonte
Jan 1996
Specialities:
Ph.D. in Biochemistry and Cellular Biotechnology
Skills
Expert in translational cancer research • biomarker discovery • and pharmacodynamics. Expert in the appl... • including cell culture (2D and 3D) • cell-base assays • flow cytometry • recombinant DNA techniques • DNA microarray • RNA interference • quantitative real-time PCR • Western blotting • ELISA • immunohistochemistry • in situ hybridization • adenoviral and lentiviral vectors • TLC • protein analysis • microscopy • and in vitro enzyme assay. Able to inter... • and their incorporation into clinical pr... • data analysis and management • and familiar with bioinformatics and dat...
Tgen
Research Assistant Professor - Tgen
Salarius Pharmaceuticals Sep 2016 - May 2018
Director of Biology
Beta Cat Pharmaceuticals May 2015 - May 2018
Director of Biology
Huntsman Cancer Institute Aug 2011 - May 2015
Senior Research Associate
University of Utah Jun 2011 - Aug 2011
Research Associate
Education:
Università Degli Studi Di Torino 1996 - 2001
Doctorates, Doctor of Philosophy, Biotechnology, Biochemistry
Università Degli Studi Di Torino 1991 - 1992
Università Degli Studi Di Torino 1984 - 1991
Bachelors, Bachelor of Science, Biology
Skills:
Molecular Biology Cell Culture Cell Biology Western Blotting Cell Biochemistry Cancer Tissue Culture Elisa Flow Cytometry Qpcr Immunohistochemistry Protein Purification
Jun 2011 to 2000 Research AssociateUniversity of Utah Salt Lake City, UT Aug 2007 to Jul 2010 Post-doctoral Research AssociateMMCRI Center for Molecular medicine, Maine Westbrook, ME Feb 2002 to Dec 2006 Post-doctoral Research FellowUniversity of Turin Torino, Piemonte Jan 1992 to May 1998 Graduate Fellow
Education:
University of Turin Torino, Piemonte Jan 1996 to Jan 2001 Ph.D. in Biochemistry and Cellular BiotechnologyUniversity of Turin Torino, Piemonte Jan 1984 to Jan 1991 BS in Biology
Skills:
Expert in translational cancer research, biomarker discovery, and pharmacodynamics. Expert in the application of various technologies and platforms to the discovery of biomarkers: in vivo and in vitro techniques, including cell culture (2D and 3D), cell-base assays, flow cytometry, recombinant DNA techniques, DNA microarray, RNA interference, quantitative real-time PCR, Western blotting, ELISA, immunohistochemistry, in situ hybridization, adenoviral and lentiviral vectors, TLC, protein analysis, microscopy, and in vitro enzyme assay. Able to interface with pre-clinical project teams to ensure appropriate qualification and validation of biomarkers and pharmacodynamic endpoints, and their incorporation into clinical protocols. Extensive experience in signal pathway analysis. Expert in automation, data analysis and management, and familiar with bioinformatics and data mining tools.
Name / Title
Company / Classification
Phones & Addresses
Raffaella Soldi Manager
Maine Medical Center Research Commercial Physical Research
81 Research Dr, Scarborough, ME 04074 (207)8858100
Us Patents
Copper-Dependent Non-Traditional Pro-Inflammatory Cytokine Export And Methods, Compositions And Kits Relating Thereto
Thomas Maciag - Portland ME, US Lorraine Maciag - South Freeport ME, US Lazar Mandinov - Ipswich MA, US Igor Prudovsky - Cape Elizabeth ME, US Stephen Bellum - South Portland ME, US Raffaella Soldi - Windham ME, US Cinzia Bagala - Rome, IT
International Classification:
A61K 33/26 A61K 38/17
US Classification:
424646000, 514012000
Abstract:
The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
Copper-Dependent Non-Traditional Pro-Inflammatory Cytokine Export And Methods, Compositions And Kits Relating Thereto
Thomas Maciag - South Freeport ME, US Lazar Mandinov - Ipswich MA, US Igor Prudovsky - Cape Elizabeth ME, US Stephen Bellum - South Portland ME, US Raffaella Soldi - Windham ME, US Cinzia Bagala - Rome, IT
Assignee:
Maine Medical Center Research Institute
International Classification:
A61K038/17 A61K031/555 A61K031/195
US Classification:
514/012000, 514/184000, 514/566000
Abstract:
The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
Youtube
World CRISPR Day 2021: Raffaella Soldi, Ph.D.
Identification of Novel Combination Therapies with the LSD1 Inhibitor ...
Duration:
21m 2s
CRISPR in Functional Genomics and Drug Discov...
... Francisco Scott Martin, Ph.D. Principal Scientific Manager, Associ...
Duration:
1h 7s
Intervista a Raffaella Carr - Che tempo che f...
Ospite a "Che tempo che fa" la regina della TV Raffaella Carr, che rip...
Duration:
19m 50s
Raffaella Carra - Fatalit - Pronto... Raffael...
Versin en italiano de "Porque el amor"
Duration:
3m 2s
Raffaella Carr - A far l'amore comincia tu (L...
Italian singer Raffaella Carr has died July 5, 2021 at the age of 78. ...
Duration:
2m 43s
TOPO GIGIO & RAFFAELLA CARRA' - Strapazzami ...
Sito Ufficiale: Facebook :Topo Gigio by Maria Perego Official FB Pla...