Abstract:
A compound of Formula Ia wherein: R and R , which are the same or different, are CF ; halogen; CN; branched or unbranched C alkyl; branched or unbranched C alkenyl; C cycloalkyl optionally substituted with OH, CN, or methoxy; C alkoxy; C alkyloxyalkyl; C alkylthio; C alkylthioalkyl; C dialkylamino; C dialkylaminoalkyl; CO R where R is C alkyl or C alkenyl optionally substituted with carbocyclyl or heterocyclyl; or aryl or heterocyclyl connected to the imidazole in any position that makes a stable bond wherein the aryl or the heterocyclyl thereof is optionally substituted with halogen, C alkyl, C alkenyl, CN, Me N, CO Me, OMe, aryl, heterocyclyl, or R ; L is âNHC(O)â; âNHC(O)Oâ; âNHC(O)C(O)â; âNHC(S)â; âNHâ; âNHC(O)NHâ; âNHC(S)NHâ; âNHCH â; âNHCH(R )â, wherein R is H, CN, C alkyl, C alkyloxyalkyl, C alkylthioalkyl, C alkylsulfinylalkyl, C alkylsulfonylalkyl, C cycloalkyl, heterocyclyl, or aryl optionally substituted with a halogen, C alkyl, CN, Me N, CO Me, or OMe; or âNHC(R )-lower alkyl; and R is C alkyl; C alkyloxy; C alkylthio; C alkylamino; C alkoxyalkyl; C alkylthioalkyl; C alkylaminoalkyl; C dialkylaminoalkyl; âCO R ; âN(R ) ; âNH(R ); âC(O)R ; âOR ; S(O) R , wherein n is 0, 1, or 2; âSO NHR ; âSO N(R ) ; or carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl thereof is optionally substituted with one or more of the following: halogen, âCN, âNO , âSO NH , CF , OCF , OC alkyl, OC alkenyl, CO C alkyl, SMe, NMe , R , or O(CH ) R , where p is 3 or 4 and R is CN, CO Me, 2-(1,3-dioxolanyl), OH, or OC H , wherein: R is phenyl, heterocyclyl, C cycloalkyl, C alkyl, C alkenyl, C alkyloxyalkyl, C alkylthioalkyl, C alkylsulfinylalkyl, C alkylsulfonylalkyl, or C alkynyl and R is optionally substituted with halogen, âOH, alkyloxy, âCN, âCOO-lower alkyl, âCONH-lower alkyl, âCON(lower alkyl) , dialkylamino, phenyl, or heterocyclyl, or a pharmaceutically acceptable derivative thereof.