Rajeev R Aurora

US Patent:

6638750, Oct 28, 2003

Filed:

Mar 10, 2000

Appl. No.:

09/523263

Inventors:

Rajeev Aurora - Chesterfield MO
Stanton B. Dotson - Fenton MO

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

C12N 910

US Classification:

435212, 4352523, 4353201, 536 232, 536 236, 530300, 530350

Abstract:

The present invention relates to a human cDNA encoding a methionine aminopeptidase type-3 (MetAP-3) protein. The invention also relates to nucleic acid molecules associated with or derived from this cDNA including complements, homologues and fragments thereof, and methods of using these nucleic acid molecules, to generate, for example, polypeptides and fragments thereof. The invention also provides methods of using the nucleic acids, for example, to produce a protein and fragments thereof and to screen for compounds or compositions that preferentially or specifically effect the activity of a MetAP-3 protein.

US Patent:

6953577, Oct 11, 2005

Filed:

Nov 19, 2002

Appl. No.:

10/299867

Inventors:

Carolyn J. Sympson - Ballwin MO, US
Rajeev Aurora - Glencoe MO, US
Stanton B. Dotson - Chesterfield MO, US
Ronald B. Frazier - Lake St. Louis MO, US
Cynthia L. Woods - St. Peters MO, US
Hamideh Zakeri - Chesterfield MO, US
Xianzhi Zhou - Chesterfield MO, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A01N063/00
C12N009/48
C12N001/20
C12N015/00
C07H021/04

US Classification:

424 9463, 435212, 4352523, 4353201, 536 232, 536 236

Abstract:

Methionine aminopeptidases catalyse the co-translational removal of amino terminal methionine residues from nascent polypeptide chains. A newly-discovered enzyme, designated methionine aminopeptidase type-3 (MetAP-3), has a substrate specificity which is similar to MetAP-1 and MetAP-2, although it is not inhibited by fumagillin, an irreversible inhibitor of MetAP-2. MetAP-3 also preferentially localizes to mitochondria, unlike MetAP-1 and MetAP-2, which accumulate in the cytoplasm. One embodiment of the present invention relates to human cDNAs encoding polypeptides comprising MetAP-3. Other embodiments of the invention relate to nucleic acid molecules derived from these cDNAs, including complements, homologues, and fragments thereof, and methods of using these nucleic acid molecules, to generate polypeptides and fragments thereof. Other embodiments of the invention relate to antibodies directed against polypeptides comprising MetAP-3, and methods to screen for compounds or compositions that preferentially or specifically effect the activity of polypeptides comprising MetAP-3.

US Patent:

20010049121, Dec 6, 2001

Filed:

Jan 12, 2001

Appl. No.:

09/759468

Inventors:

Sherin Abdel-Meguid - Exton PA, US
Rajeev Aurora - Chesterfield MO, US
Preston Hensley - Chester Springs PA, US
George Rose - Glen Arm MD, US
Peter Young - Lawrenceville NJ, US
Yuan Zhu - Blue Bell PA, US

International Classification:

C07H021/04
A61K031/70
A01N043/04
C12P021/06
A61K045/00
C07K001/00
C07K014/00
C07K017/00

US Classification:

435/069100, 435/006000, 530/351000, 424/085100, 536/023500, 514/044000

Abstract:

2-19 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing 2-19 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

US Patent:

20080318207, Dec 25, 2008

Filed:

Jun 23, 2008

Appl. No.:

12/144030

Inventors:

Rajeev Aurora - Wildwood MO, US
Maureen J. Donlin - Kirkwood MO, US
John E. Tavis - Kirkwood MO, US

Assignee:

Saint Louis University - St. Louis MO

International Classification:

C12Q 1/70
C12Q 1/00
C12Q 1/68
G01N 33/53

US Classification:

435 5, 435 6, 435 4, 435 71

Abstract:

Methods of identifying targets for designing a therapeutic agent are disclosed. These methods comprise: determining an amino acid sequence of one or more polypeptides of each isolate of a plurality of isolates of a biological system; identifying covariance pairs of amino acid residues; establishing a network comprising the covariance pairs; and identifying one or more hub residue positions, wherein a hub residue position comprises a target for designing a therapeutic agent if the hub residue position has a rank order in the 40percentile or greater. In other aspects, methods are disclosed for selecting a therapy for an infectious disorder. In various configurations, these methods comprise: determining amino acids occupying a plurality of diagnostic amino acid residue positions comprised by one or more polypeptides encoded by an infectious agent infecting a subject; and assigning the infectious agent infecting the subject to one covariance network selected from a plurality of covariance networks, wherein each network comprises a unique rank order of hubs with respect to the other networks, and whereby the therapy is selected on the basis of the covariance network assignment.

US Patent:

20120173155, Jul 5, 2012

Filed:

Dec 30, 2011

Appl. No.:

13/341410

Inventors:

Rajeev Aurora - Wildwood MO, US
John Tavis - Kirkwood MO, US

Assignee:

ST. LOUIS UNIVERSITY - St. Louis MO

International Classification:

G06F 19/24

US Classification:

702 19

Abstract:

The present invention generally relates to a computer-implemented method for predicting a response of a virus to antiviral therapy, and finds particular use in predicting a response of a Hepatitis C or Hepatitis B virus isolated from a patient.

US Patent:

20120283958, Nov 8, 2012

Filed:

Apr 24, 2012

Appl. No.:

13/454673

Inventors:

Rajeev Aurora - Wildwood MO, US
John Edwin Tavis - Kirkwood MO, US

Assignee:

SAINT LOUIS UNIVERSITY - St. Louis MO

International Classification:

G06F 19/00

US Classification:

702 20

Abstract:

Methods for predicting a response of a virus to an antiviral therapy are provided.

US Patent:

20130034888, Feb 7, 2013

Filed:

Aug 3, 2012

Appl. No.:

13/566009

Inventors:

Rajeev Aurora - Wildwood MO, US
Shelley D. Minteer - Salt Lake City UT, US

International Classification:

C12P 7/16
G01N 21/64
C12P 7/40

US Classification:

435136, 435160, 436 94

Abstract:

Disclosed are methods for detecting cellulose in cellulosic materials and producing alcohol using cellulosic materials. More particularly, disclosed are methods for producing alcohol in a cell-free system by contacting pyruvate with enzymes from a minimal enzymatic pathway. Also disclosed are methods of producing pyruvate by culturing a microorganism under hypoxic conditions. Disclosed are methods for detecting cellulose in a sample using Congo red dye.

US Patent:

62455508, Jun 12, 2001

Filed:

Mar 20, 1998

Appl. No.:

9/045193

Inventors:

Sherin S Abdel-Meguid - Exton PA
Rajeev Aurora - Chesterfield MO
Derk J Bergsma - Berwyn PA
Catherine E Ellis - Glassboro NJ
Stephanie F Guerrera - Philadelphia PA
Preston Hensley - Chester Springs PA
Jeffrey L Mooney - Limerick PA
George D Rose - Glen Arm MD
Peter R Young - Lawrenceville NJ
Yuan Zhu - Blue Bell PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 121

US Classification:

4352523

Abstract:

EF-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EF-7 polypeptides and polynucleotides in therapy, and diagnostic assays for such.