Rajender R Leleti

US Patent:

20120252778, Oct 4, 2012

Filed:

Mar 26, 2012

Appl. No.:

13/429726

Inventors:

Wolfgang MILTZ - Basel, CH
Berndt OBERHAUSER - Riehen, CH
Andrea VAUPEL - Riehen, CH
Juraj VELCICKY - Basel, CH
Klaus WEIGAND - Bettingen, CH
Rajender Reddy LELETI - Randolph NJ, US
Yugang LIU - Bridgewater NJ, US
Zhengming DU - Parsippany NJ, US

Assignee:

NOVARTIS AG - Basel

International Classification:

A61K 31/519
A61P 19/10
A61P 1/02
A61P 19/08
A61P 35/00
A61P 3/00
A61P 9/00
A61P 9/10
A61P 27/02
A61P 19/02
A61P 29/00
A61P 17/02
A61P 17/00
A61P 11/00
A61P 11/06
A61P 11/08
A61P 31/00
A61P 33/02
A61P 33/06
A61P 33/08
A61P 35/04
A61P 21/00
A61P 37/06
A61P 37/00
A61P 13/12
A61P 1/00
A61P 37/02
C07D 487/04

US Classification:

51421021, 544281, 5142593, 51425216

Abstract:

The present invention relates to pyrazolo pyrimidine derivatives, to methods of preparing these, to combinations and pharmaceutical composition comprising these, and to their use in the treatment of diseases and disorders which may for example involve autoimmune diseases, angiogenesis, pain, and/or inflammatory diseases.

US Patent:

20120302756, Nov 29, 2012

Filed:

Feb 17, 2011

Appl. No.:

13/576427

Inventors:

Rajender Reddy Leleti - East Hanover NJ, US
Yugang Liu - East Hanover NJ, US
Mahavir Prashad - East Hanover NJ, US

International Classification:

C07D 211/96
C07D 203/24

US Classification:

546184, 548965

Abstract:

The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

US Patent:

20130079328, Mar 28, 2013

Filed:

Jun 28, 2011

Appl. No.:

13/701982

Inventors:

Dai Cheng - San Diego CA, US
Guobao Zhang - San Diego CA, US
Dong Han - San Diego CA, US
Wenqi Gao - San Diego CA, US
Shifeng Pan - San Diego CA, US
Lichun Shen - Ledgewood NJ, US
Rajender Reddy Leleti - Randolph NJ, US

International Classification:

C07D 417/14
A61K 45/06
A61K 31/541
C07D 237/08
A61K 31/50

US Classification:

51421018, 544224, 514247, 544 582, 5142278, 435375

Abstract:

The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R, R, Rare as defined herein.

US Patent:

20110112121, May 12, 2011

Filed:

Jun 30, 2010

Appl. No.:

12/827218

Inventors:

Joerg BERGHAUSEN - Basel, CH
Claire HAUG - Basel, CH
Michael HERBIG - Basel, CH
Bin HU - East Hanover NJ, US
Stéphane JONAT - Basel, CH
Rajender LELETI - East Hanover NJ, US
Josef Gottfried MEINGASSNER - Vienna, AT
Stéphanie MONNIER - Cedex Compiegne, FR
Matthias NAPP - Basel, CH
Mahavir PRASHAD - East Hanover NJ, US
Anton STÜTZ - Wien, AT
Ranjit THAKUR - Basel, CH

International Classification:

A61K 31/505
A61P 17/00
A61P 17/06
C07D 239/02

US Classification:

514269, 544319

Abstract:

The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide.