Long non-coding RNAs (lincRNAs), a relatively recently recognized class of widely transcribed genes, are thought to affect chromatin state and epigenetic regulation, but their mechanisms of action and potential roles in human disease are poorly understood. The present invention shows that long non-coding RNAs in the human HOX loci are systematically dysregulated during breast cancer progression, and that expression levels of the lincRNA termed HOTAIR can predict cancer metastasis. Elevated levels of HOTAIR can lead to altered patterns of Polycomb binding to the genome. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
- Santa Clara CA, US Sriram Sellappa - Santa Clara CA, US Rajnish Gupta - Fremont CA, US
International Classification:
H04L 45/741 H04L 45/00 H04L 45/748
Abstract:
In some embodiments, a method sets a threshold for utilization of a first table, wherein the utilization is based on layer addresses and layer addresses being stored in the first table. When a utilization of the first table does not meet the threshold, the method stores a layer address in the first table. The first table uses a first type of lookup to determine a next hop address for the layer addresses or the layer addresses, and the first table also stores one or more layer addresses. When the utilization of the first table meets the threshold, the method stores the layer address in a second table where the second table uses a second type of lookup to determine the next hop address for layer addresses.
- Santa Clara CA, US Sriram Sellappa - Santa Clara CA, US Rajnish Gupta - Fremont CA, US
International Classification:
H04L 12/749 H04L 12/745 H04L 12/721 H04L 12/733
Abstract:
In some embodiments, a method sets a threshold for utilization of a first table, wherein the utilization is based on layer 3 addresses and layer 2 addresses being stored in the first table. When a utilization of the first table does not meet the threshold, the method stores a layer 3 address in the first table. The first table uses a first type of lookup to determine a next hop address for the layer 3 addresses or the layer 2 addresses, and the first table also stores one or more layer 2 addresses. When the utilization of the first table meets the threshold, the method stores the layer 3 address in a second table where the second table uses a second type of lookup to determine the next hop address for layer 3 addresses.
American Health Network IncAmerican Health Network 85 Commerce Park Dr, Westerville, OH 43082 (614)8822397 (phone), (614)8985999 (fax)
Education:
Medical School Univ Coll of Med Sciences, Delhi Univ, New Delhi, Delhi, India Graduated: 1985
Languages:
English Spanish
Description:
Dr. Gupta graduated from the Univ Coll of Med Sciences, Delhi Univ, New Delhi, Delhi, India in 1985. He works in Westerville, OH and specializes in Family Medicine. Dr. Gupta is affiliated with Mount Carmel St Anns Hospital.
Stanford University
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