Ralph U Brown

US Patent:

20050232986, Oct 20, 2005

Filed:

Dec 17, 2003

Appl. No.:

10/736902

Inventors:

David Brown - Colleyville TX, US
Ralph Brown - Southlake TX, US
Himanshu Patel - North Richland Hills TX, US
Viswanathan Srinivasan - The Woodlands TX, US

International Classification:

A61K031/5415
A61K031/485
A61K009/20
A61K009/24

US Classification:

424464000, 514282000, 514225800

Abstract:

A pharmaceutical dosage form which comprises promethazine and/or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of promethazine or salt thereof. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

US Patent:

20050232993, Oct 20, 2005

Filed:

Apr 27, 2005

Appl. No.:

11/115293

Inventors:

David Brown - Colleyville TX, US
Ralph Brown - Southlake TX, US
Himanshu Patel - North Richland Hills TX, US
Viswanathan Srinivasan - The Woodlands TX, US

Assignee:

SOVEREIGN PHARMACEUTICALS, LTD. - Fort Worth TX

International Classification:

A61K031/60
A61K031/485
A61K031/192

US Classification:

424468000, 514282000, 514570000, 514165000, 514649000

Abstract:

A pharmaceutical dosage form which comprises promethazine and/or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of promethazine or salt thereof. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

US Patent:

20080292699, Nov 27, 2008

Filed:

May 25, 2007

Appl. No.:

11/753621

Inventors:

Ralph BROWN - Southlake TX, US
David BROWN - Colleyville TX, US
Suresh DIXIT - Fort Worth TX, US

Assignee:

SOVEREIGN PHARMACEUTICALS, LTD. - Fort Worth TX

International Classification:

A61K 9/24
A61K 31/439
A61K 31/137
A61K 31/435
A61P 43/00

US Classification:

424468, 514291, 514653, 514646, 514357

Abstract:

A solid pharmaceutical dosage unit for alleviating the symptoms of rhinorrhea. The dosage unit comprises an anticholinergic agent and an antihistamine and, optionally, a decongestant and, when placed in a basket in 500 ml of 0.01 N HCl of 37 C. which is stirred at 100 rpm, releases at least about 75% of the at least one anticholinergic agent within 45 minutes and releases the at least one antihistamine at a rate of from about 20% to about 60% after 2 hours, from about 45% to about 80% after 4 hours and at least about 75% after 8 hours. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

US Patent:

56875541, Nov 18, 1997

Filed:

Jan 4, 1996

Appl. No.:

8/582725

Inventors:

Ralph T. Brown - Allen TX

International Classification:

B65B 1304

US Classification:

53589

Abstract:

Apparatus for applying a flexible strap to an article, such as a roll of paper product, in a predetermined position with respect to a surface on the article, such as an end face of a roll, and in proper alignment with the end face to prevent loosening of the strap at a later time. A generally plate-like guide member has a strap guide surface thereon and a strapping head for feeding the strap around the guide surface for engagement with the article to be strapped. The guide member is mounted on linear bearings for translation with respect to a support frame. A spherical bearing is interposed between the linear bearing and the guide member to allow the guide member to be skewed with respect to the linear bearings to align itself with the end face or other surface on the article to be strapped. A series of pressure fluid piston and cylinder actuator positioning devices are mounted on the guide member and are engageable with the end face or other surface of the article to be strapped for proper positioning of the guide member and the strap for application to the article. The guide member is moved in opposite directions by two stage pressure fluid cylinder and piston actuators which may be actuated to center the guide member on the machine between two conveyors for the article, an upstream position and a downstream position for application of a strap to one or more ends of the article.

US Patent:

20160213656, Jul 28, 2016

Filed:

Apr 1, 2016

Appl. No.:

15/088537

Inventors:

- Fort Worth TX, US
Ralph BROWN - Southlake TX, US
David BROWN - Colleyville TX, US
Himanshu PATEL - North Richland Hills TX, US
Juan Carlos MENENDEZ - Bedford TX, US
Somphet Peter SUPHASAWUD - Fort Worth TX, US

International Classification:

A61K 31/439

Abstract:

A method of alleviating or treating a condition which can be alleviated or treated by administering hyoscyamine comprises administering to a subject in need thereof a pharmaceutical dosage form which comprises at least one of hyoscyamine and a pharmaceutically acceptable salt thereof. The dosage form comprises two or more hyoscyamine formulations, at least one of the formulations being an immediate release formulation and at least one other one being a controlled release formulation.