Scott F. Michael - Estero FL, US Sharon Isern - Estero FL, US Robert Garry - New Orleans LA, US Ram Samudrala - Mukilteo WA, US Joshua Costin - Naples FL, US Ekachai Jenwitheesuk - Ratchaburi, TH
The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.
Scott F. Michael - Estero FL, US Sharon Isern - Estero FL, US Joshua Costin - Naples FL, US Ram Samudrala - Mukilteo WA, US Ekachai Jenwitheesuk - Ratchaburi, TH
Assignee:
FLORIDA GULF COAST UNIVERSITY - Ft. Myers FL
International Classification:
A61K 38/10 C07K 7/08 C12Q 1/70 A61P 31/14
US Classification:
514 37, 530326, 514 214, 435 5
Abstract:
The invention relates peptide entry inhibitors and methods of determining such inhibitors that are bindable to regions of viruses having class II E proteins, such as the dengue virus E protein, as candidates for in vivo anti-viral compounds.
Compositions And Methods For Predicting Inhibitors Of Protein Targets
Compositions and methods are provided for predicting inhibitors of protein targets related to treatment of infectious disease, for example, bacterial, viral, or parasitic diseases. Methods are provided for predicting inhibitors of protein targets related to treatment infectious disease, for example, microbial disease, utilizing a docking with dynamics protocol to identify inhibitors, or utilizing a protein structure energy function to identify peptide or peptidomimetic inhibitors.
University of Washington Feb 1, 2001 - Sep 30, 2014
Associate Professor
3D Therapeutics Feb 1, 2001 - Sep 30, 2014
Owner
Education:
St. Joseph's Indian High School
Ohio Wesleyan University
Center For Advanced Research In Biotechnology (Umbi)
Doctorates, Doctor of Philosophy, Biology
Stanford University