Gary Arthur Amstutz - San Jose CA Stephen Scott Bowersox - Menlo Park CA Kishorchandra Gohil - Richmond CA Peter Isadore Adriaenssens - Mountain View CA Ramasharma Kristipati - Fremont CA
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
A61K 3800 A61K 3802 C07K 500 C07K 700
US Classification:
514 12
Abstract:
A method of preventing progression of neuropathic pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking compound which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention.
Gary Arthur Amstutz - San Jose CA Stephen Scott Bowersox - Menlo Park CA Kishorchandra Gohil - Richmond CA Peter Isadore Adriaenssens - Mountain View CA Ramasharma Kristipati - Fremont CA
Assignee:
Neurex Corporation - Menlo Park CA
International Classification:
A61K 3800 C07K 500 C07K 700
US Classification:
514 12
Abstract:
Disclosed are formulations effective to stabilize omega conotoxin peptide preparations at elevated temperatures. Novel omega conopeptides also form part of the invention.